Depression and survival in patients with non-small cell lung cancer after curative resection: A preliminary study

Naoki Nakaya, Kumi Saito-Nakaya, Nobuya Akizuki, Eisho Yoshikawa, Makoto Kobayakawa, Maiko Fujimori, Kanji Nagai, Yutaka Nishiwaki, Shin Fukudo, Yoshitaka Tsubono, Yosuke Uchitomi

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29 Citations (Scopus)


Psychological depression is thought to be a predictor of poor survival among cancer patients. The objective of the present study was to investigate the association between depression and survival in surgically treated Japanese patients with non-small cell lung cancer (NSCLC). From June 1996 through April 1999, a total of 229 patients with postoperative lung cancer were enrolled. Three months after the patients' surgery, the Structured Clinical Interview for DSM-III-R (SCID) and the Profile of Mood States (POMS) were used to assess the patient for depression, based on the interviewers' rating and a self-report, respectively. The follow-up period consisted of a total of 14 342 person-months (median = 69 months). As of January 2004, 55 deaths had occurred within the follow-up period. A Cox regression was used to estimate the hazard ratio (HR) of mortality adjusting for age, sex, smoking status, occasion of diagnosis, pathological stage and preoperative percentage forced expiratory volume in 1 s. The depression-dejection subscale on the POMS was divided into three score levels. The multivariate HR of survival for individuals with depression, as diagnosed by the SCID, was 2.2 (95% confidence interval 0.8-6.0) (P-VALUE = 0.14), compared with individuals without depression. The multivariate HR of survival for subjects in the highest level of the POMS Depression-Dejection subscale was 1.4 (0.7-2.6), compared with in the lowest level (trend P-value = 0.0502). This prospective cohort study in Japan does not support the hypothesis that depression is associated with survival among NSCLS patients after curative resection, but further analysis involving a long-term follow-up period needed.

Original languageEnglish
Pages (from-to)199-205
Number of pages7
JournalCancer science
Issue number3
Publication statusPublished - 2006 Mar

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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