Dephosphorylation of eNOS on Thr495 after transient forebrain ischemia in gerbil hippocampus

Akihito Hashiguchi, Shigetoshi Yano, Motohiro Morioka, Junichiro Hamada, Masato Kochi, Kohji Fukunaga

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


We investigated phosphorylation of endothelial nitric oxide synthase (eNOS) at two major sites, Ser1177 and Thr495, which has a critical role to control its activity, in the gerbil hippocampal microvasculature after transient forebrain ischemia. Ser1177 phosphorylation was unchanged by 24 h after reperfusion, despite post-ischemic up-regulation of eNOS protein. However, Thr495 phosphorylation significantly and persistently decreased by 48 h. We here defined the changes in eNOS phosphorylation in vivo following brain ischemia/reperfusion. (ischemia).

Original languageEnglish
Pages (from-to)317-319
Number of pages3
JournalMolecular Brain Research
Issue number2
Publication statusPublished - 2005 Feb 18
Externally publishedYes


  • Cerebral ischemia
  • Nitric oxide
  • Phosphorylation
  • eNOS

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience


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