Deoxycorticosterone-secreting adrenocortical carcinoma

Akihiro Yamamoto; Takushi Naroda; Susumu Kagawa; Yoshihumi Umaki; Yasumi Shintani; Toshiaki Sano; Hironobu Sasano

doi:10.1007/BF02915306

Deoxycorticosterone-secreting adrenocortical carcinoma

Akihiro Yamamoto, Takushi Naroda, Susumu Kagawa, Yoshihumi Umaki, Yasumi Shintani, Toshiaki Sano, Hironobu Sasano

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

A case of DOC-secreting adrenocortical carcinoma in a 66-year-old man is reported. He had hypertension, hypokalemia, suppressed PRA, and excessive serum levels of DOC. His serum aldosterone level was normal. The resected adrenal mass weighed 230 g. Histologically, the tumor was mainly composed of compact cells associated with necrosis and atypical mitoses. Invasion of venous structure, sinusoids, and capsule was also present. Immunohistochemically, P450 C21 (21 -hydroxylase) was positive in many tumor cells, and P450 C17(17 α-hydroxylase) was intensely positive in a relatively small number of tumor cells. The patient died 9 months after operation due to rupture of metastatic liver tumor. Endocr Pathol 4:165-168, 1993.

Original language	English
Pages (from-to)	165-168
Number of pages	4
Journal	Endocrine Pathology
Volume	4
Issue number	3
DOIs	https://doi.org/10.1007/BF02915306
Publication status	Published - 1993 Sept

ASJC Scopus subject areas

Pathology and Forensic Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1007/BF02915306

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title = "Deoxycorticosterone-secreting adrenocortical carcinoma",

abstract = "A case of DOC-secreting adrenocortical carcinoma in a 66-year-old man is reported. He had hypertension, hypokalemia, suppressed PRA, and excessive serum levels of DOC. His serum aldosterone level was normal. The resected adrenal mass weighed 230 g. Histologically, the tumor was mainly composed of compact cells associated with necrosis and atypical mitoses. Invasion of venous structure, sinusoids, and capsule was also present. Immunohistochemically, P450 C21 (21 -hydroxylase) was positive in many tumor cells, and P450 C17(17 α-hydroxylase) was intensely positive in a relatively small number of tumor cells. The patient died 9 months after operation due to rupture of metastatic liver tumor. Endocr Pathol 4:165-168, 1993.",

author = "Akihiro Yamamoto and Takushi Naroda and Susumu Kagawa and Yoshihumi Umaki and Yasumi Shintani and Toshiaki Sano and Hironobu Sasano",

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T1 - Deoxycorticosterone-secreting adrenocortical carcinoma

AU - Yamamoto, Akihiro

AU - Naroda, Takushi

AU - Kagawa, Susumu

AU - Umaki, Yoshihumi

AU - Shintani, Yasumi

AU - Sano, Toshiaki

AU - Sasano, Hironobu

PY - 1993/9

Y1 - 1993/9

N2 - A case of DOC-secreting adrenocortical carcinoma in a 66-year-old man is reported. He had hypertension, hypokalemia, suppressed PRA, and excessive serum levels of DOC. His serum aldosterone level was normal. The resected adrenal mass weighed 230 g. Histologically, the tumor was mainly composed of compact cells associated with necrosis and atypical mitoses. Invasion of venous structure, sinusoids, and capsule was also present. Immunohistochemically, P450 C21 (21 -hydroxylase) was positive in many tumor cells, and P450 C17(17 α-hydroxylase) was intensely positive in a relatively small number of tumor cells. The patient died 9 months after operation due to rupture of metastatic liver tumor. Endocr Pathol 4:165-168, 1993.

AB - A case of DOC-secreting adrenocortical carcinoma in a 66-year-old man is reported. He had hypertension, hypokalemia, suppressed PRA, and excessive serum levels of DOC. His serum aldosterone level was normal. The resected adrenal mass weighed 230 g. Histologically, the tumor was mainly composed of compact cells associated with necrosis and atypical mitoses. Invasion of venous structure, sinusoids, and capsule was also present. Immunohistochemically, P450 C21 (21 -hydroxylase) was positive in many tumor cells, and P450 C17(17 α-hydroxylase) was intensely positive in a relatively small number of tumor cells. The patient died 9 months after operation due to rupture of metastatic liver tumor. Endocr Pathol 4:165-168, 1993.

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ER -

Deoxycorticosterone-secreting adrenocortical carcinoma

Abstract

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