Deoxycorticosterone-secreting adrenocortical carcinoma

Akihiro Yamamoto, Takushi Naroda, Susumu Kagawa, Yoshihumi Umaki, Yasumi Shintani, Toshiaki Sano, Hironobu Sasano

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


A case of DOC-secreting adrenocortical carcinoma in a 66-year-old man is reported. He had hypertension, hypokalemia, suppressed PRA, and excessive serum levels of DOC. His serum aldosterone level was normal. The resected adrenal mass weighed 230 g. Histologically, the tumor was mainly composed of compact cells associated with necrosis and atypical mitoses. Invasion of venous structure, sinusoids, and capsule was also present. Immunohistochemically, P450 C21 (21 -hydroxylase) was positive in many tumor cells, and P450 C17(17 α-hydroxylase) was intensely positive in a relatively small number of tumor cells. The patient died 9 months after operation due to rupture of metastatic liver tumor. Endocr Pathol 4:165-168, 1993.

Original languageEnglish
Pages (from-to)165-168
Number of pages4
JournalEndocrine Pathology
Issue number3
Publication statusPublished - 1993 Sept

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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