Dendritic Eph organizes dendrodendritic segregation in discrete olfactory map formation in Drosophila

Marie Anzo, Sayaka Sekine, Shirin Makihara, Kinhong Chao, Masayuki Miura, Takahiro Chihara

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Proper function of the neural network results from the precise connections between axons and dendrites of presynaptic and postsynaptic neurons, respectively. In the Drosophila olfactory system, the dendrites of projection neurons (PNs) stereotypically target one of ∼50 glomeruli in the antennal lobe (AL), the primary olfactory center in the brain, and form synapses with the axons of olfactory receptor neurons (ORNs). Here, we show that Eph and Ephrin, the well-known axon guidance molecules, instruct the dendrodendritic segregation during the discrete olfactory map formation. The Eph receptor tyrosine kinase is highly expressed and localized in the glomeruli related to reproductive behavior in the developing AL. In one of the pheromone-sensing glomeruli (DA1), the Eph cell-autonomously regulates its dendrites to reside in a single glomerulus by interacting with Ephrins expressed in adjacent PN dendrites. Our data demonstrate that the trans interaction between dendritic Eph and Ephrin is essential for the PN dendritic boundary formation in the DA1 olfactory circuit, potentially enabling strict segregation of odor detection between pheromones and the other odors.

Original languageEnglish
Pages (from-to)1054-1065
Number of pages12
JournalGenes and Development
Volume31
Issue number10
DOIs
Publication statusPublished - 2017 May 15
Externally publishedYes

Keywords

  • Dendrite
  • Drosophila
  • Eph
  • Ephrin
  • Wiring

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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