TY - JOUR
T1 - Dendritic cells play a crucial role in innate immunity to simple chemicals
AU - Aiba, Setsuya
AU - Tagami, Hachiro
N1 - Funding Information:
This study was supported in part by grants 10670776 (Dr Aiba), 08307009 (Dr Tamaki) and 10877163 (Dr Tagami) from the Ministry of Education, Science, and Culture of Japan.
PY - 1999
Y1 - 1999
N2 - Recently, it has been demonstrated that immunity to infectious agents is composed of innate immunity and acquired immunity, and that dendritic cells (DC) and macrophages, both of which are the participants in the innate immunity, play a crucial role in acquired immune responses, via their expression of several costimulatory molecules and production of cytokines. It is clear that the immune system responds not only to infectious organisms but also to simple chemicals. Allergic contact hypersensitivity reaction is a good example of the immune response to simple chemicals. In contrast to the immunity to microorganisms, however, the role of the innate immune system in responses to simple chemicals still remains unclear. This paper demonstrates that the activation and apoptosis of DC are directly induced by certain simple chemicals, and we suggest that DC, as cells involved in the innate immune system, play a crucial role in the immunity to simple chemicals.
AB - Recently, it has been demonstrated that immunity to infectious agents is composed of innate immunity and acquired immunity, and that dendritic cells (DC) and macrophages, both of which are the participants in the innate immunity, play a crucial role in acquired immune responses, via their expression of several costimulatory molecules and production of cytokines. It is clear that the immune system responds not only to infectious organisms but also to simple chemicals. Allergic contact hypersensitivity reaction is a good example of the immune response to simple chemicals. In contrast to the immunity to microorganisms, however, the role of the innate immune system in responses to simple chemicals still remains unclear. This paper demonstrates that the activation and apoptosis of DC are directly induced by certain simple chemicals, and we suggest that DC, as cells involved in the innate immune system, play a crucial role in the immunity to simple chemicals.
KW - Contact hypersensitivity
KW - Costimulatory molecules
KW - Hapten
KW - Innate immunity
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U2 - 10.1038/sj.jidsp.5640201
DO - 10.1038/sj.jidsp.5640201
M3 - Article
C2 - 10536992
AN - SCOPUS:0032851194
VL - 4
SP - 158
EP - 163
JO - Journal of Investigative Dermatology Symposium Proceedings
JF - Journal of Investigative Dermatology Symposium Proceedings
SN - 1087-0024
IS - 2
ER -