Dendritic cells and contact dermatitis

Yoshinori Sasaki, Setsuya Aiba

Research output: Contribution to journalReview articlepeer-review

25 Citations (Scopus)


Contact dermatitis is a biological response to simple chemicals in the skin. Although it is well known that allergic contact dermatitis is mediated by the immune system, it is still uncertain whether it is a kind of protective response or it is simply an unnecessary response. We have demonstrated the following: (1) haptens activate Langerhans cells in the initiation phase of murine allergic contact dermatitis in vivo, (2) haptens activate human monocyte-derived dendritic cells in vitro, (3) the activation of dendritic cells by haptens is primarily mediated by the activation of p38 mitogen-activated protein kinase (MAPK), and (4) the activation of p38 MAPK is mediated by stimulation related to an imbalance of intracellular redox. Based on these observations, we will discuss the biological significance of contact dermatitis. In addition, we will review some up-to-date findings on Langerhans cell biology.

Original languageEnglish
Pages (from-to)27-34
Number of pages8
JournalClinical Reviews in Allergy and Immunology
Issue number1-2
Publication statusPublished - 2007 Oct


  • Contact dermatitis
  • Dendritic cells
  • Knock-in mice
  • Langerhans cells
  • Redox balance
  • p38 Mitogen-activated protein kinase

ASJC Scopus subject areas

  • Immunology and Allergy


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