Delta-like 4 and vasohibin 1: Two endothelium-produced negative regulators of angiogenesis with distinctive roles

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)

Abstract

Angiogenesis is regulated by the local balance between angiogenesis stimulators and inhibitors. A number of endogenous angiogenesis inhibitors have been found in the body. The origin of these inhibitors is mostly extrinsic to the vasculature. Recently however, endothelial cells themselves have been found to produce angiogenesis inhibitors including delta-like 4 and vasohibin 1. These intrinsic factors are thought to regulate angiogenesis by an autoregulatory or negative-feedback mechanism. This review focuses on such negative regulators of angiogenesis produced by endothelial cells.

Original languageEnglish
Pages (from-to)220-224
Number of pages5
JournalEuropean Cytokine Network
Volume20
Issue number4
DOIs
Publication statusPublished - 2009 Dec 1

Keywords

  • Angiogenesis
  • Autoregulation
  • Endothelium
  • Negative feedback

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Clinical Biochemistry

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