Delineation of molecular determinants for FR900359 inhibition of G_q/11 unlocks inhibition of Ga_s

Medicine & Life Sciences

• FR900359 100%
• YM-254890 72%
• Gases 40%
• GTP-Binding Proteins 15%
• Binding Sites 12%
• Intracellular Signaling Peptides and Proteins 8%
• Gq-G11 GTP-Binding Protein alpha Subunits 8%
• Heterotrimeric GTP-Binding Proteins 7%
• Guanosine Triphosphate 5%
• G-Protein-Coupled Receptors 5%
• Biological Products 5%

Chemical Compounds

• G12 31%
• Gas 25%
• Protein 19%
• Binding Site 13%
• Amino-Acid Residue 8%
• Mutation 8%
• Occurrence in Nature 7%