Deletion mapping of chromosome 10 in human glioma

Yukihiko Sonoda, Yoshinori Murakami, Teiji Tominaga, Takamasa Kayama, Takashi Yoshimoto, Takao Sekiya

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38 Citations (Scopus)

Abstract

We analyzed DNAs from 35 gliomas (27 malignant, grades III and IV; 8 less malignant, grades I and II) for loss of heterozygosity (LOH) using microsatellite sequences on chromosome 10 as polymorphic markers. An LOH was found in 8 of 11 (73%) glioblastomas (grade IV) and 4 of 16 (25%) grade III gliomas, but not in the less malignant types, We detected three commonly deleted regions. One was located in a telomeric region of 10p and the others were relatively large regions of 10q. Our results suggested that three putative tumor suppressor genes on chromosome 10 are involved in the malignant progression of gliomas.

Original languageEnglish
Pages (from-to)363-367
Number of pages5
JournalJapanese Journal of Cancer Research
Volume87
Issue number4
DOIs
Publication statusPublished - 1996 Apr

Keywords

  • Deletion map
  • Human glioma
  • LOH on chromosome 10
  • Microsatellite sequences
  • Tumor suppressor gene

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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