Deletion mapping of chromosome 10 in human glioma

Yukihiko Sonoda; Yoshinori Murakami; Teiji Tominaga; Takamasa Kayama; Takashi Yoshimoto; Takao Sekiya

doi:10.1111/j.1349-7006.1996.tb00231.x

Deletion mapping of chromosome 10 in human glioma

Yukihiko Sonoda, Yoshinori Murakami, Teiji Tominaga, Takamasa Kayama, Takashi Yoshimoto, Takao Sekiya

University Hospital (not affiliated with any section)

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

We analyzed DNAs from 35 gliomas (27 malignant, grades III and IV; 8 less malignant, grades I and II) for loss of heterozygosity (LOH) using microsatellite sequences on chromosome 10 as polymorphic markers. An LOH was found in 8 of 11 (73%) glioblastomas (grade IV) and 4 of 16 (25%) grade III gliomas, but not in the less malignant types, We detected three commonly deleted regions. One was located in a telomeric region of 10p and the others were relatively large regions of 10q. Our results suggested that three putative tumor suppressor genes on chromosome 10 are involved in the malignant progression of gliomas.

Original language	English
Pages (from-to)	363-367
Number of pages	5
Journal	Japanese Journal of Cancer Research
Volume	87
Issue number	4
DOIs	https://doi.org/10.1111/j.1349-7006.1996.tb00231.x
Publication status	Published - 1996 Apr

Keywords

Deletion map
Human glioma
LOH on chromosome 10
Microsatellite sequences
Tumor suppressor gene

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1349-7006.1996.tb00231.x

Cite this

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title = "Deletion mapping of chromosome 10 in human glioma",

abstract = "We analyzed DNAs from 35 gliomas (27 malignant, grades III and IV; 8 less malignant, grades I and II) for loss of heterozygosity (LOH) using microsatellite sequences on chromosome 10 as polymorphic markers. An LOH was found in 8 of 11 (73%) glioblastomas (grade IV) and 4 of 16 (25%) grade III gliomas, but not in the less malignant types, We detected three commonly deleted regions. One was located in a telomeric region of 10p and the others were relatively large regions of 10q. Our results suggested that three putative tumor suppressor genes on chromosome 10 are involved in the malignant progression of gliomas.",

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T1 - Deletion mapping of chromosome 10 in human glioma

AU - Sonoda, Yukihiko

AU - Murakami, Yoshinori

AU - Tominaga, Teiji

AU - Kayama, Takamasa

AU - Yoshimoto, Takashi

AU - Sekiya, Takao

PY - 1996/4

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N2 - We analyzed DNAs from 35 gliomas (27 malignant, grades III and IV; 8 less malignant, grades I and II) for loss of heterozygosity (LOH) using microsatellite sequences on chromosome 10 as polymorphic markers. An LOH was found in 8 of 11 (73%) glioblastomas (grade IV) and 4 of 16 (25%) grade III gliomas, but not in the less malignant types, We detected three commonly deleted regions. One was located in a telomeric region of 10p and the others were relatively large regions of 10q. Our results suggested that three putative tumor suppressor genes on chromosome 10 are involved in the malignant progression of gliomas.

AB - We analyzed DNAs from 35 gliomas (27 malignant, grades III and IV; 8 less malignant, grades I and II) for loss of heterozygosity (LOH) using microsatellite sequences on chromosome 10 as polymorphic markers. An LOH was found in 8 of 11 (73%) glioblastomas (grade IV) and 4 of 16 (25%) grade III gliomas, but not in the less malignant types, We detected three commonly deleted regions. One was located in a telomeric region of 10p and the others were relatively large regions of 10q. Our results suggested that three putative tumor suppressor genes on chromosome 10 are involved in the malignant progression of gliomas.

KW - Deletion map

KW - Human glioma

KW - LOH on chromosome 10

KW - Microsatellite sequences

KW - Tumor suppressor gene

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Deletion mapping of chromosome 10 in human glioma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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