Deleted in esophageal cancer 1(DEC1) is down-regulated and contributes to migration in head and neck squamous cell carcinoma cell lines

Yasuomi Kunimoto, Seiji Nakano, Hideyuki Kataoka, Yutaka Shimada, Mitsuo Oshimura, Hiroya Kitano

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Previous studies have shown that the expression of Deleted in Esophageal Cancer 1 (DEC1) is significantly reduced in esophageal squamous cell carcinoma. Patients with head and neck squamous cell carcinoma (HNSCC) often develop esophageal carcinomas. Materials and Methods: We analyzed the expression of DEC1 and histone modifications in HNSCC cell lines. The motility and invasive ability of the HNSCC cell lines were also studied. Results: Of 18 cell lines, 12 (66.7%) showed down-regulation of DEC1. Chromatin immunoprecipitation assays indicated that H3 K27 trimethylation levels in the DEC1-down-regulated cell lines were greater than that in the DEC1-expressed cell lines. Migration assays showed that the DEC1-down-regulated cell lines tended to be more motile than the DEC1-expressed cell lines. Conclusion:DEC1 is down-regulated and tends to contribute to the migration ability of HNSCC cell lines. In addition, H3 K27 trimethylation potentially plays an important role in the regulation of DEC1 expression.

Original languageEnglish
Pages (from-to)17-23
Number of pages7
JournalORL
Volume73
Issue number1
DOIs
Publication statusPublished - 2011 Jan

Keywords

  • DEC1
  • Head and neck squamous cell carcinoma
  • Histone H3 K27 trimethylation
  • Invasion
  • Migration
  • Tumor suppressor gene

ASJC Scopus subject areas

  • Otorhinolaryngology

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