TY - JOUR
T1 - Delayed visual NA potential in remitted schizophrenia
T2 - A new vulnerability marker for psychotic relapse under low-dose medication
AU - Matsuoka, Hiroo
AU - Matsumoto, Kazunori
AU - Yamazaki, Hisato
AU - Yoshida, Sumiko
AU - Numachi, Yohtaro
AU - Saito, Hidemitsu
AU - Ueno, Takashi
AU - Sato, Mitsumoto
N1 - Funding Information:
This research was supported by a Research Grant for Nervous and Mental Disorders from the Ministry of Health and Welfare of Japan.
PY - 1999/1/1
Y1 - 1999/1/1
N2 - Background: Lasting cognitive dysfunction throughout remission has been regarded as a biological vulnerability in schizophrenia, which may produce psychotic relapses with characteristic symptoms. Our hypothesis was that an abnormality in event-related potentials (ERPs) may be a neurophysiological marker of vulnerability to psychotic relapse in remitted schizophrenia. We conducted a 2-year follow-up study after evaluating ERP abnormalities to find a new ERP marker for schizophrenic relapse. Methods: Visual ERPs were recorded from outpatients with remitted schizophrenia under maintenance pharmacotherapy (n = 44) and normal controls (n = 20) during a letter discrimination task. Based on the prospective study, the patients were divided into a relapse group (n = 20) and a nonrelapse group (n = 24). ERP findings that related to psychotic relapse within 2 years were analyzed. Results: Compared with controls, the relapsers showed ERP abnormalities in the NA, N2, and P3 components, and the nonrelapsers in the P3 component. The peak latency of the NA potential was delayed significantly in the relapse group relative to the nonrelapse group, and predicted a psychotic relapse with about 90% probability. Conclusions: The delayed NA, which reflects early perceptual disorganization, may be a promising neurophysiological predictor of psychotic relapse in remitted schizophrenia under maintenance pharmacotherapy.
AB - Background: Lasting cognitive dysfunction throughout remission has been regarded as a biological vulnerability in schizophrenia, which may produce psychotic relapses with characteristic symptoms. Our hypothesis was that an abnormality in event-related potentials (ERPs) may be a neurophysiological marker of vulnerability to psychotic relapse in remitted schizophrenia. We conducted a 2-year follow-up study after evaluating ERP abnormalities to find a new ERP marker for schizophrenic relapse. Methods: Visual ERPs were recorded from outpatients with remitted schizophrenia under maintenance pharmacotherapy (n = 44) and normal controls (n = 20) during a letter discrimination task. Based on the prospective study, the patients were divided into a relapse group (n = 20) and a nonrelapse group (n = 24). ERP findings that related to psychotic relapse within 2 years were analyzed. Results: Compared with controls, the relapsers showed ERP abnormalities in the NA, N2, and P3 components, and the nonrelapsers in the P3 component. The peak latency of the NA potential was delayed significantly in the relapse group relative to the nonrelapse group, and predicted a psychotic relapse with about 90% probability. Conclusions: The delayed NA, which reflects early perceptual disorganization, may be a promising neurophysiological predictor of psychotic relapse in remitted schizophrenia under maintenance pharmacotherapy.
KW - Event-related potential
KW - NA potential
KW - Psychotic relapse
KW - Schizophrenia
KW - Vulnerability
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U2 - 10.1016/S0006-3223(97)00526-X
DO - 10.1016/S0006-3223(97)00526-X
M3 - Article
C2 - 9894582
AN - SCOPUS:0032967993
VL - 45
SP - 107
EP - 115
JO - Biological Psychiatry
JF - Biological Psychiatry
SN - 0006-3223
IS - 1
ER -