Delayed emergence of oseltamivir-resistant seasonal influenza A (H1N1) and pandemic influenza A(H1N1)pdm09 viruses in Myanmar

Clyde Dapat; Reiko Saito; Yadanar Kyaw; Yi Yi Myint; Htun Naing Oo; Khin Yi Oo; Makoto Naito; Go Hasegawa; Isolde C. Dapat; Hiroshi Suzuki

doi:10.1111/irv.12030

Delayed emergence of oseltamivir-resistant seasonal influenza A (H1N1) and pandemic influenza A(H1N1)pdm09 viruses in Myanmar

Clyde Dapat, Reiko Saito, Yadanar Kyaw, Yi Yi Myint, Htun Naing Oo, Khin Yi Oo, Makoto Naito, Go Hasegawa, Isolde C. Dapat, Hiroshi Suzuki

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

The prevalence and timing of emergence of oseltamivir-resistant seasonal and pandemic influenza A (H1N1) viruses in Myanmar in 2008 and 2009 are described in this report. In 2008, the oseltamivir-resistant seasonal H1N1 virus was detected at a lower rate (6%) and emerged at least 2months later when compared with neighboring countries. Similarly, the prevalence of pandemic H1N1 virus was low (3%) and the timing of emergence was late (August 2009) in Myanmar. Interestingly, we detected three isolates that were resistant to both amantadine and oseltamivir. Limited movement of people into the country is attributed to the delayed emergence of drug-resistant seasonal and pandemic A(H1N1) viruses.

Original language	English
Pages (from-to)	766-771
Number of pages	6
Journal	Influenza and other Respiratory Viruses
Volume	7
Issue number	5
DOIs	https://doi.org/10.1111/irv.12030
Publication status	Published - 2013 Sep
Externally published	Yes

Keywords

Amantadine
Antiviral drug resistance
H1N1 subtype
Oseltamivir
Pandemic influenza
Seasonal influenza

ASJC Scopus subject areas

Epidemiology
Pulmonary and Respiratory Medicine
Public Health, Environmental and Occupational Health
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/irv.12030

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title = "Delayed emergence of oseltamivir-resistant seasonal influenza A (H1N1) and pandemic influenza A(H1N1)pdm09 viruses in Myanmar",

abstract = "The prevalence and timing of emergence of oseltamivir-resistant seasonal and pandemic influenza A (H1N1) viruses in Myanmar in 2008 and 2009 are described in this report. In 2008, the oseltamivir-resistant seasonal H1N1 virus was detected at a lower rate (6%) and emerged at least 2months later when compared with neighboring countries. Similarly, the prevalence of pandemic H1N1 virus was low (3%) and the timing of emergence was late (August 2009) in Myanmar. Interestingly, we detected three isolates that were resistant to both amantadine and oseltamivir. Limited movement of people into the country is attributed to the delayed emergence of drug-resistant seasonal and pandemic A(H1N1) viruses.",

keywords = "Amantadine, Antiviral drug resistance, H1N1 subtype, Oseltamivir, Pandemic influenza, Seasonal influenza",

author = "Clyde Dapat and Reiko Saito and Yadanar Kyaw and Myint, {Yi Yi} and Oo, {Htun Naing} and Oo, {Khin Yi} and Makoto Naito and Go Hasegawa and Dapat, {Isolde C.} and Hiroshi Suzuki",

year = "2013",

month = sep,

doi = "10.1111/irv.12030",

language = "English",

volume = "7",

pages = "766--771",

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TY - JOUR

T1 - Delayed emergence of oseltamivir-resistant seasonal influenza A (H1N1) and pandemic influenza A(H1N1)pdm09 viruses in Myanmar

AU - Dapat, Clyde

AU - Saito, Reiko

AU - Kyaw, Yadanar

AU - Myint, Yi Yi

AU - Oo, Htun Naing

AU - Oo, Khin Yi

AU - Naito, Makoto

AU - Hasegawa, Go

AU - Dapat, Isolde C.

AU - Suzuki, Hiroshi

PY - 2013/9

Y1 - 2013/9

N2 - The prevalence and timing of emergence of oseltamivir-resistant seasonal and pandemic influenza A (H1N1) viruses in Myanmar in 2008 and 2009 are described in this report. In 2008, the oseltamivir-resistant seasonal H1N1 virus was detected at a lower rate (6%) and emerged at least 2months later when compared with neighboring countries. Similarly, the prevalence of pandemic H1N1 virus was low (3%) and the timing of emergence was late (August 2009) in Myanmar. Interestingly, we detected three isolates that were resistant to both amantadine and oseltamivir. Limited movement of people into the country is attributed to the delayed emergence of drug-resistant seasonal and pandemic A(H1N1) viruses.

AB - The prevalence and timing of emergence of oseltamivir-resistant seasonal and pandemic influenza A (H1N1) viruses in Myanmar in 2008 and 2009 are described in this report. In 2008, the oseltamivir-resistant seasonal H1N1 virus was detected at a lower rate (6%) and emerged at least 2months later when compared with neighboring countries. Similarly, the prevalence of pandemic H1N1 virus was low (3%) and the timing of emergence was late (August 2009) in Myanmar. Interestingly, we detected three isolates that were resistant to both amantadine and oseltamivir. Limited movement of people into the country is attributed to the delayed emergence of drug-resistant seasonal and pandemic A(H1N1) viruses.

KW - Amantadine

KW - Antiviral drug resistance

KW - H1N1 subtype

KW - Oseltamivir

KW - Pandemic influenza

KW - Seasonal influenza

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ER -

Delayed emergence of oseltamivir-resistant seasonal influenza A (H1N1) and pandemic influenza A(H1N1)pdm09 viruses in Myanmar

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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