Degradation of Bioactive Polydimethylsiloxane-CaO-SiO2-TiO 2 and Poly(tetramethylene oxide)-CaO-TiO2 Hybrids in a Simulated Body Fluid

Masanobu Kamitakahara, Masakazu Kawashita, Noboru Miyata, Tadashi Kokubo, Takashi Nakamura

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


It has been shown that polydimethylsiloxane (PDMS)-CaO-SiO 2-TiO2 and poly(tetramethylene oxide) (PTMO)-CaO-TiO 2 hybrids form apatite on their surfaces in a simulated body fluid (SBF) and show mechanical properties similar to those of human cancellous bones. In the present study, changes, caused by soaking in SBF, were measured in the mechanical properties of PDMS-CaO-SiO2-TiO2 hybrids with different CaO and TiO2 contents and PTMO-CaO-TiO2 hybrids with different CaO contents. Significant decreases in the strength and strain at failure of the hybrids were observed for the PDMS-CaO-SiO 2-TiO2 hybrids with high CaO or TiO2 contents and PTMO-CaO-TiO2 hybrids with a high CaO content after soaking in SBF for 4 w. This indicates that incorporation of a large amount of CaO component into the hybrids should result in the deterioration of the hybrids in the body environment.

Original languageEnglish
Pages (from-to)235-239
Number of pages5
JournalJournal of the American Ceramic Society
Issue number2
Publication statusPublished - 2004 Feb

ASJC Scopus subject areas

  • Ceramics and Composites
  • Materials Chemistry

Fingerprint Dive into the research topics of 'Degradation of Bioactive Polydimethylsiloxane-CaO-SiO<sub>2</sub>-TiO <sub>2</sub> and Poly(tetramethylene oxide)-CaO-TiO<sub>2</sub> Hybrids in a Simulated Body Fluid'. Together they form a unique fingerprint.

Cite this