Deformation of stenotic blood vessel model made from Poly (Vinyl Alcohol) Hydrogel by hydrostatic pressure

Yasutomo Shimizu, Lei Liu, Hiroyuki Kosukegawa, Kenichi Funamoto, Toshiyuki Hayase, Toshio Nakayama, Makoto Ohta

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Vascular plaque deformation reduces blood flow, increases arterial embolism risk, and may lead to ischemic stroke. Plaque stiffness varies widely and is an important factor influencing both plaque and parent artery deformation. These geometric changes affect local hemodynamics, which impact plaque initiation influencing disease progression. However, most previous studies used non-elastic stenotic vessel models. For more realistic analysis, we constructed a stenosis model comprising an elastic poly (vinyl alcohol) hydrogel (PVA-H) parent artery and plaque of variable stiffness. Our previous study using this flexible model demonstrated substantial effects of hydrostatic pressure. Here ultrasonography was conducted under changing hydrostatic pressure to measure geometric changes at the narrowest cross section. PVA-H specimens were constructed with the stiffness of a hard lipid core, smooth muscle, and plaque, as estimated by tensile tests using 5, 12, and 15 wt% PVA, respectively. The change in cross-sectional aspect ratio (height/face length) at the narrowest site is largest (~1.3) for the 5 wt% PVA-H plaque and smallest (~1.2) for the 12 wt% PVA-H plaque. Stenotic artery deformation depends on both artery and plaque elasticity. Hydrostatic pressure has a substantial effect on both vessel and plaque geometries, which markedly alter blood flow.

Original languageEnglish
Title of host publicationBiomedical and Biotechnology Engineering
PublisherAmerican Society of Mechanical Engineers (ASME)
ISBN (Electronic)9780791850534
DOIs
Publication statusPublished - 2016
EventASME 2016 International Mechanical Engineering Congress and Exposition, IMECE 2016 - Phoenix, United States
Duration: 2016 Nov 112016 Nov 17

Publication series

NameASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)
Volume3

Other

OtherASME 2016 International Mechanical Engineering Congress and Exposition, IMECE 2016
Country/TerritoryUnited States
CityPhoenix
Period16/11/1116/11/17

Keywords

  • Hydrostatic pressure.
  • Plaque
  • Poly(vinyl alcohol) hydrogel

ASJC Scopus subject areas

  • Mechanical Engineering

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