Deformation and Alignment of Arterial Endothelial Cells along Blood Flow (A Computational Fluid Mechanical Study)

Takami Yamaguchi

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

The mechanism of arterial endothelial cell deformation and alignment was studied using a threedimensional computational fluid mechanical model of the arteriolar wall with regularly arranged intraluminal undulation simulating endothelial cells. Endothelial cells were simulated using a 2D Gaussian distribution function, which had three parameters used to define the shape of the cells. They were the elongation factor, which is the correlation coefficient of the Gaussian distribution function, the height of the cells, and the cellular angle against the blood flow. The Navier-Stokes equations of the Newtonian fluid under steady flow conditions were solved using a finite volume method, and the absolute wall shear stress (WSS) at the summit of the cells was calculated. The WSS at the nuclear bulge varied in a complex manner, and the hypothesis that the endothelial cells change their shape and alignment to minimize the WSS at the nuclear bulge was presented to explain the computed results.

Original languageEnglish
Pages (from-to)3665-3671
Number of pages7
JournalTransactions of the Japan Society of Mechanical Engineers Series B
Volume60
Issue number579
DOIs
Publication statusPublished - 1994

Keywords

  • Adaptation
  • Artery
  • Atherosclerosis
  • BioFluid Mechanics
  • Blood Flow
  • Computational Fluid Dynamics
  • Deformation and Alignment of the Endothelial Cells
  • Endothelial Cells
  • Finite Volume Method
  • Hemodynamics
  • Pipe Flow
  • Wall Shear Stress

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Mechanical Engineering

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