Definition of terminology and criteria for ambulatory blood pressure monitoring in the Japanese Multicenter Study on Barnidipine with Ambulatory Blood Pressure Monitoring

Yutaka Imai, Kazuyuki Shimada, Iwao Kuwajima, Keishi Abe

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

The Japanese Multicenter Study on Barnidipine with Ambulatory Blood Pressure Monitoring (J-MUBA) was a nationwide clinical study conducted to evaluate the antihypertensive action of the long-acting calcium antagonist, barnidipine hydrochloride, as a single agent, particularly its effect on circadian blood pressure variation, in hypertensive patients. Patient recruitment began in 1995, and the results were reported in 1999. A total of 612 patients attending 121 medical institutions in Japan were registered. Ambulatory blood pressure monitoring (ABPM) was performed before barnidipine was initiated and after a 6-month administration period. Data processing methods, definitions of terminology, and criteria for hypertension and normotension during ABPM were determined by the 15 Central Committee members and 11 Protocol Committee members before the study began to avoid arbitrary analyses. This paper details the data processing methods, definitions of terminology, and criteria for hypertension and normotension for ABPM utilized in J-MUBA. Previous studies lacked comprehensive definitions and criteria for determining circadian blood pressure variation. Thus if the definitions and criteria for ambulatory blood pressure (ABP) used in J-MUBA are commonly used in the analysis of ABP worldwide, it will become possible to compare the results of various studies.

Original languageEnglish
Pages (from-to)S9-S15
JournalBlood pressure monitoring
Volume6
Issue numberSUPPL. 2
Publication statusPublished - 2001

Keywords

  • Ambulatory blood pressure monitoring
  • Dippers
  • Morning hypertension
  • Non-dippers
  • Smoothness index
  • Trough/peak ratio
  • White-coat hypertension

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Assessment and Diagnosis
  • Advanced and Specialised Nursing

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