Defining the Optimal Method for Measuring Metabolic Tumor Volume on Preoperative 18F-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography as a Prognostic Predictor in Patients With Pancreatic Ductal Adenocarcinoma

Yasuko Tatewaki, Chiaki Maeda Terao, Kyohei Ariake, Ryoko Saito, Tatsushi Mutoh, Hideo Shimomura, Fuyuhiko Motoi, Masamichi Mizuma, Hayato Odagiri, Michiaki Unno, Yasuyuki Taki

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: Metabolic tumor volume (MTV) on 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) is a promising prognostic predictor in pancreatic ductal adenocarcinoma (PDAC). However, the optimal segmentation method and threshold value to determine MTV for PDAC are still unclear. We explored the optimal method and threshold value for the prognostic value of MTV measured on pre-treatment 18F-FDG-PET/CT. Methods: Seventy-three patients with resected PDAC who underwent 18F FDG-PET/CT before surgical resection were enrolled. MTV values of the tumor were measured on FDG-PET/CT by the two fixed-threshold methods using threshold values as 2.0, 2.5, 3.0, and 3.5 for the absolute method and 35%, 40%, 42%, 45%, and 50% for the relative method. Receiver operating characteristic curve analysis for prediction of 1-year survival rates was conducted for determining the optimal threshold values, and we selected the optimal method and threshold value considering area under the curve. The prognostic values of each FDG-PET/CT parameter for disease-specific survival and recurrence-free survival were assessed with Kaplan–Meier method and Cox proportional hazard models. Results: In receiver operating characteristic curve analysis, MTV by the fixed-absolute threshold method based on a threshold value of 3.5 (MTV3.5) performed best in our study with area under the curve 0.724, sensitivity of 65%, and specificity of 75%. In univariate and multivariate analyses, MTV3.5 was significantly associated with disease-specific and recurrence-free survival. Conclusions: MTV3.5 by absolute threshold on pre-treatment FDG-PET/CT was the best independent prognostic predictor in resectable PDAC compared with other absolute threshold values and relative threshold values.

Original languageEnglish
Article number646141
JournalFrontiers in Oncology
Volume11
DOIs
Publication statusPublished - 2021 Mar 12

Keywords

  • FDG PET = F-18 fluorodeoxyglucose positron emission tomography
  • PDAC=pancreatic ductal adenocarcinoma
  • metabolic tumor volume (MTV)
  • prognosis
  • threshold

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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