Defining a role for acid sphingomyelinase in the p38/interleukin-6 pathway

David M. Perry; Benjamin Newcomb; Mohamad Adada; Bill X. Wu; Patrick Roddy; Kazuyuki Kitatani; Leah Siskind; Lina M. Obeid; Yusuf A. Hannun

doi:10.1074/jbc.M114.589648

Defining a role for acid sphingomyelinase in the p38/interleukin-6 pathway

David M. Perry, Benjamin Newcomb, Mohamad Adada, Bill X. Wu, Patrick Roddy, Kazuyuki Kitatani, Leah Siskind, Lina M. Obeid, Yusuf A. Hannun

Tohoku Medical Megabank Organization (ToMMo)

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Background: Sphingolipids are important in multiple biological processes, but there is a lack of understanding of the pathways that mediate these effects. Results: Acid sphingomyelinase is involved in p38 activation, interleukin-6 production, and cancer cell invasion. Conclusion: Acid sphingomyelinase plays a role in inflammatory, proinvasive signaling in cancer cells. Significance: This work expands the understanding of acid sphingomyelinase signaling and downstream biology.

Original language	English
Pages (from-to)	22401-22412
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	289
Issue number	32
DOIs	https://doi.org/10.1074/jbc.M114.589648
Publication status	Published - 2014 Aug 8

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Defining a role for acid sphingomyelinase in the p38/interleukin-6 pathway. / Perry, David M.; Newcomb, Benjamin; Adada, Mohamad; Wu, Bill X.; Roddy, Patrick; Kitatani, Kazuyuki; Siskind, Leah; Obeid, Lina M.; Hannun, Yusuf A.

In: Journal of Biological Chemistry, Vol. 289, No. 32, 08.08.2014, p. 22401-22412.

Research output: Contribution to journal › Article › peer-review

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AU - Roddy, Patrick

AU - Kitatani, Kazuyuki

AU - Siskind, Leah

AU - Obeid, Lina M.

AU - Hannun, Yusuf A.

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