Defining a role for acid sphingomyelinase in the p38/interleukin-6 pathway

David M. Perry, Benjamin Newcomb, Mohamad Adada, Bill X. Wu, Patrick Roddy, Kazuyuki Kitatani, Leah Siskind, Lina M. Obeid, Yusuf A. Hannun

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Background: Sphingolipids are important in multiple biological processes, but there is a lack of understanding of the pathways that mediate these effects. Results: Acid sphingomyelinase is involved in p38 activation, interleukin-6 production, and cancer cell invasion. Conclusion: Acid sphingomyelinase plays a role in inflammatory, proinvasive signaling in cancer cells. Significance: This work expands the understanding of acid sphingomyelinase signaling and downstream biology.

Original languageEnglish
Pages (from-to)22401-22412
Number of pages12
JournalJournal of Biological Chemistry
Issue number32
Publication statusPublished - 2014 Aug 8

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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