Deficit in Thyroid Hormone Transporters and Brain Development

Research output: Chapter in Book/Report/Conference proceedingChapter


1.Thyroid hormone is essential for the development of various tissues, especially in the developing brain.2.Several classes of transporters, such as organic anion transporting polypeptides (OATP1C1/Oatp1c1), monocarboxylate transporters (Mct8/MCT8), and amino acid transporters (Lat1/LAT1), are expressed in different components of the central nervous system (i.e., blood brain barrier, astrocytes, and neurons), functioning concertedly (see Fig. 11.1).3.The fact that only MCT8 and Oatp1c1 double knockout mice displayed more severely decreased uptakes and contents of T3 and T4 in brain as well as exhibited more impaired brain development phenotypes (delayed cerebellar development, reduced myelination, and abnormal locomotor activities), suggesting compensations and redundancies of thyroid hormone transportation in the brain by several different transporters.

Original languageEnglish
Title of host publicationContemporary Clinical Neuroscience
PublisherSpringer Nature
Number of pages14
Publication statusPublished - 2016

Publication series

NameContemporary Clinical Neuroscience
ISSN (Print)2627-535X
ISSN (Electronic)2627-5341


  • Amino acid transporter
  • Blood–brain barrier
  • Monocarboxylate transporter
  • Organic anion transporting polypeptide
  • Thyroid hormone transporter
  • Type2 deiodinase
  • Type3 deiodinase

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Neurology
  • Sensory Systems
  • Clinical Neurology


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