TY - CHAP
T1 - Deficit in Thyroid Hormone Transporters and Brain Development
AU - Suzuki, Takehiro
AU - Abe, Takaaki
N1 - Publisher Copyright:
© 2016, Springer Science+Business Media New York.
PY - 2016
Y1 - 2016
N2 - 1.Thyroid hormone is essential for the development of various tissues, especially in the developing brain.2.Several classes of transporters, such as organic anion transporting polypeptides (OATP1C1/Oatp1c1), monocarboxylate transporters (Mct8/MCT8), and amino acid transporters (Lat1/LAT1), are expressed in different components of the central nervous system (i.e., blood brain barrier, astrocytes, and neurons), functioning concertedly (see Fig. 11.1).3.The fact that only MCT8 and Oatp1c1 double knockout mice displayed more severely decreased uptakes and contents of T3 and T4 in brain as well as exhibited more impaired brain development phenotypes (delayed cerebellar development, reduced myelination, and abnormal locomotor activities), suggesting compensations and redundancies of thyroid hormone transportation in the brain by several different transporters.
AB - 1.Thyroid hormone is essential for the development of various tissues, especially in the developing brain.2.Several classes of transporters, such as organic anion transporting polypeptides (OATP1C1/Oatp1c1), monocarboxylate transporters (Mct8/MCT8), and amino acid transporters (Lat1/LAT1), are expressed in different components of the central nervous system (i.e., blood brain barrier, astrocytes, and neurons), functioning concertedly (see Fig. 11.1).3.The fact that only MCT8 and Oatp1c1 double knockout mice displayed more severely decreased uptakes and contents of T3 and T4 in brain as well as exhibited more impaired brain development phenotypes (delayed cerebellar development, reduced myelination, and abnormal locomotor activities), suggesting compensations and redundancies of thyroid hormone transportation in the brain by several different transporters.
KW - Amino acid transporter
KW - Blood–brain barrier
KW - Monocarboxylate transporter
KW - Organic anion transporting polypeptide
KW - Thyroid hormone transporter
KW - Type2 deiodinase
KW - Type3 deiodinase
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U2 - 10.1007/978-1-4939-3737-0_11
DO - 10.1007/978-1-4939-3737-0_11
M3 - Chapter
AN - SCOPUS:85117470244
T3 - Contemporary Clinical Neuroscience
SP - 169
EP - 182
BT - Contemporary Clinical Neuroscience
PB - Springer Nature
ER -