TY - JOUR
T1 - Defibrinogenation therapy for idiopathic sudden sensorineural hearing loss in comparison with high-dose steroid therapy
AU - Suzuki, Hideaki
AU - Furukawa, Masayuki
AU - Kumagai, Masaki
AU - Takahashi, Etsu
AU - Matsuura, Kazuto
AU - Katori, Yukio
AU - Shimomura, Akira
AU - Kobayashi, Toshimitsu
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2003
Y1 - 2003
N2 - Objective - The efficacy of defibrinogenation therapy for idiopathic sudden sensorineural hearing loss was studied in comparison with high-dose steroid therapy. Material and methods - Eighty-eight consecutive patients with hearing levels > 40 dB and who had suffered hearing loss for ≤ 30 days were enrolled: 40 patients for high-dose steroid therapy (PSL group) and 48 for defibrinogenation therapy (BX group). Hearing recovery was evaluated by grade assessment and by the improvement in hearing compared to the unaffected contralateral ear. Results - The overall hearing outcomes of the two groups were roughly equivalent. However, with regard to patients with initial hearing levels < 80 dB, the hearing improvement rate of the BX group was significantly worse than that of the PSL group (61.2% ± 7.3% vs 88.7% ± 8.9%; p < 0.05), whereas in patients with initial hearing levels ≥ 80 dB, the hearing outcomes did not differ between the 2 groups. Three patients in the PSL group manifested hyperglycemia while no serious side-effects were observed in the BX group. Conclusion - These results indicate that high-dose steroid therapy should be employed in preference to defibrinogenation therapy for patients with moderate hearing loss, whereas defibrinogenation therapy has an advantage for those with severe hearing loss, in view of its lower frequency of side-effects.
AB - Objective - The efficacy of defibrinogenation therapy for idiopathic sudden sensorineural hearing loss was studied in comparison with high-dose steroid therapy. Material and methods - Eighty-eight consecutive patients with hearing levels > 40 dB and who had suffered hearing loss for ≤ 30 days were enrolled: 40 patients for high-dose steroid therapy (PSL group) and 48 for defibrinogenation therapy (BX group). Hearing recovery was evaluated by grade assessment and by the improvement in hearing compared to the unaffected contralateral ear. Results - The overall hearing outcomes of the two groups were roughly equivalent. However, with regard to patients with initial hearing levels < 80 dB, the hearing improvement rate of the BX group was significantly worse than that of the PSL group (61.2% ± 7.3% vs 88.7% ± 8.9%; p < 0.05), whereas in patients with initial hearing levels ≥ 80 dB, the hearing outcomes did not differ between the 2 groups. Three patients in the PSL group manifested hyperglycemia while no serious side-effects were observed in the BX group. Conclusion - These results indicate that high-dose steroid therapy should be employed in preference to defibrinogenation therapy for patients with moderate hearing loss, whereas defibrinogenation therapy has an advantage for those with severe hearing loss, in view of its lower frequency of side-effects.
KW - Batroxobin
KW - Defibrinogenation therapy
KW - High-dose steroid therapy
KW - Idiopathic sudden sensorineural hearing loss
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U2 - 10.1080/0036554021000028082
DO - 10.1080/0036554021000028082
M3 - Article
C2 - 12625572
AN - SCOPUS:0037274918
VL - 123
SP - 46
EP - 50
JO - Acta Oto-Laryngologica
JF - Acta Oto-Laryngologica
SN - 0001-6489
IS - 1
ER -