Defective IL-2-mediated IL-2 receptor α chain expression in Stat3-deficient T lymphocytes

Hiroshi Akaishi, Kiyoshi Takeda, Tsuneyasu Kaisho, Ryuzaburo Shineha, Susumu Satomi, Junji Takeda, Shizuo Akira

Research output: Contribution to journalArticlepeer-review

70 Citations (Scopus)


Stat3, a member of signal transducers and activators of transcription (STAT), is activated by a variety of cytokines. Recently, mice lacking Stat3 specifically in T cells have been generated and shown to be defective in IL-6-induced proliferation due to the impairment in IL-6-mediated prevention of apoptosis. In the present study, we show that Stat3-deficient T cells are partially defective in IL-2-induced proliferation. Stat3-deficient T cells show impaired IL-2-mediated IL-2 receptor (IL-2R) α chain expression. When Stat3-deficient T cells are stimulated with high-dose IL-2, these T cells express IL-2Rα and proliferate to similar extents as wild-type T cells. These demonstrate that Stat3 activation is required for efficient T cell proliferation by IL-2 through IL-2Rα induction. Taken together, these findings demonstrate that Stat3 activation in T cells is responsible for IL-2- and IL-6-induced proliferation through distinct mechanisms.

Original languageEnglish
Pages (from-to)1747-1751
Number of pages5
JournalInternational immunology
Issue number11
Publication statusPublished - 1998
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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