Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans

Shinobu Saijo, Noriyuki Fujikado, Takahisa Furuta, Soo Hyun Chung, Hayato Kotaki, Keisuke Seki, Katsuko Sudo, Shizuo Akira, Yoshiyuki Adachi, Naohito Ohno, Takeshi Kinjo, Kiwamu Nakamura, Kazuyoshi Kawakami, Yoichiro Iwakura

Research output: Contribution to journalArticlepeer-review

470 Citations (Scopus)

Abstract

Dectin-1 is a C-type lectin involved in the recognition of β-glucans found in the cell walls of fungi. We generated dectin-1-deficient mice to determine the importance of dectin-1 in the defense against pathogenic fungi. In vitro, β-glucan-induced cytokine production from wild-type dendritic cells and macrophages was abolished in cells homozygous for dectin-1 deficiency ('dectin-1-knockout' cells). In vivo, dectin-1-knockout mice were more susceptible than wild-type mice to pneumocystis infection, even though their cytokine production was normal. However, pneumocystis-infected dectin-1-knockout macrophages did show defective production of reactive oxygen species. In contrast to those results, wild-type and dectin-1-knockout mice were equally susceptible to candida infection. Thus, dectin-1 is required for immune responses to some fungal infections, as protective immunity to pneumocystis, but not to candida, required dectin-1 for the production of antifungal reactive oxygen species.

Original languageEnglish
Pages (from-to)39-46
Number of pages8
JournalNature Immunology
Volume8
Issue number1
DOIs
Publication statusPublished - 2007 Jan

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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