Dectin-1 is not required for the host defense to Cryptococcus neoformans

Kiwamu Nakamura; Takeshi Kinjo; Shinobu Saijo; Akiko Miyazato; Yoshiyuki Adachi; Naohito Ohno; Jiro Fujita; Mitsuo Kaku; Yoichiro Iwakura; Kazuyoshi Kawakami

doi:10.1111/j.1348-0421.2007.tb04007.x

Dectin-1 is not required for the host defense to Cryptococcus neoformans

Kiwamu Nakamura, Takeshi Kinjo, Shinobu Saijo, Akiko Miyazato, Yoshiyuki Adachi, Naohito Ohno, Jiro Fujita, Mitsuo Kaku, Yoichiro Iwakura, Kazuyoshi Kawakami

Research output: Contribution to journal › Article

60 Citations (Scopus)

Abstract

Dectin-1 is known as a sole receptor for β-glucan, a major cell wall component of fungal microorganisms. In the current study, we examined the role of this molecule in the host defense to Cryptococcus neoformans, an opportunistic fungal pathogen in AIDS patients. There was no significant difference in the clinical course and cytokine production between dectin-1 gene-deficient and control mice. These results indicate that dectin-1 is not likely essential for the development of host protective responses to C. neoformans.

Original language	English
Pages (from-to)	1115-1119
Number of pages	5
Journal	MICROBIOLOGY and IMMUNOLOGY
Volume	51
Issue number	11
DOIs	https://doi.org/10.1111/j.1348-0421.2007.tb04007.x
Publication status	Published - 2007

Keywords

Cryptococcus neoformans
Dectin-1
Dendritic cells
Host defense
IL-12

ASJC Scopus subject areas

Microbiology
Immunology
Virology

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Nakamura, K., Kinjo, T., Saijo, S., Miyazato, A., Adachi, Y., Ohno, N., Fujita, J., Kaku, M., Iwakura, Y., & Kawakami, K. (2007). Dectin-1 is not required for the host defense to Cryptococcus neoformans. MICROBIOLOGY and IMMUNOLOGY, 51(11), 1115-1119. https://doi.org/10.1111/j.1348-0421.2007.tb04007.x

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AU - Adachi, Yoshiyuki

AU - Ohno, Naohito

AU - Fujita, Jiro

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AU - Kawakami, Kazuyoshi

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