Dectin-1 is not required for the host defense to Cryptococcus neoformans

Kiwamu Nakamura, Takeshi Kinjo, Shinobu Saijo, Akiko Miyazato, Yoshiyuki Adachi, Naohito Ohno, Jiro Fujita, Mitsuo Kaku, Yoichiro Iwakura, Kazuyoshi Kawakami

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Dectin-1 is known as a sole receptor for β-glucan, a major cell wall component of fungal microorganisms. In the current study, we examined the role of this molecule in the host defense to Cryptococcus neoformans, an opportunistic fungal pathogen in AIDS patients. There was no significant difference in the clinical course and cytokine production between dectin-1 gene-deficient and control mice. These results indicate that dectin-1 is not likely essential for the development of host protective responses to C. neoformans.

Original languageEnglish
Pages (from-to)1115-1119
Number of pages5
JournalMICROBIOLOGY and IMMUNOLOGY
Volume51
Issue number11
DOIs
Publication statusPublished - 2007

Keywords

  • Cryptococcus neoformans
  • Dectin-1
  • Dendritic cells
  • Host defense
  • IL-12

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology

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    Nakamura, K., Kinjo, T., Saijo, S., Miyazato, A., Adachi, Y., Ohno, N., Fujita, J., Kaku, M., Iwakura, Y., & Kawakami, K. (2007). Dectin-1 is not required for the host defense to Cryptococcus neoformans. MICROBIOLOGY and IMMUNOLOGY, 51(11), 1115-1119. https://doi.org/10.1111/j.1348-0421.2007.tb04007.x