Dectin-1 is not required for the host defense to Cryptococcus neoformans

Kiwamu Nakamura; Takeshi Kinjo; Shinobu Saijo; Akiko Miyazato; Yoshiyuki Adachi; Naohito Ohno; Jiro Fujita; Mitsuo Kaku; Yoichiro Iwakura; Kazuyoshi Kawakami

doi:10.1111/j.1348-0421.2007.tb04007.x

Dectin-1 is not required for the host defense to Cryptococcus neoformans

Kiwamu Nakamura, Takeshi Kinjo, Shinobu Saijo, Akiko Miyazato, Yoshiyuki Adachi, Naohito Ohno, Jiro Fujita, Mitsuo Kaku, Yoichiro Iwakura, Kazuyoshi Kawakami

Research output: Contribution to journal › Article › peer-review

65 Citations (Scopus)

Abstract

Dectin-1 is known as a sole receptor for β-glucan, a major cell wall component of fungal microorganisms. In the current study, we examined the role of this molecule in the host defense to Cryptococcus neoformans, an opportunistic fungal pathogen in AIDS patients. There was no significant difference in the clinical course and cytokine production between dectin-1 gene-deficient and control mice. These results indicate that dectin-1 is not likely essential for the development of host protective responses to C. neoformans.

Original language	English
Pages (from-to)	1115-1119
Number of pages	5
Journal	MICROBIOLOGY and IMMUNOLOGY
Volume	51
Issue number	11
DOIs	https://doi.org/10.1111/j.1348-0421.2007.tb04007.x
Publication status	Published - 2007

Keywords

Cryptococcus neoformans
Dectin-1
Dendritic cells
Host defense
IL-12

ASJC Scopus subject areas

Microbiology
Immunology
Virology

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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10.1111/j.1348-0421.2007.tb04007.x

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Dectin-1 is not required for the host defense to Cryptococcus neoformans. / Nakamura, Kiwamu; Kinjo, Takeshi; Saijo, Shinobu; Miyazato, Akiko; Adachi, Yoshiyuki; Ohno, Naohito; Fujita, Jiro; Kaku, Mitsuo; Iwakura, Yoichiro; Kawakami, Kazuyoshi.

In: MICROBIOLOGY and IMMUNOLOGY, Vol. 51, No. 11, 2007, p. 1115-1119.

Research output: Contribution to journal › Article › peer-review

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abstract = "Dectin-1 is known as a sole receptor for β-glucan, a major cell wall component of fungal microorganisms. In the current study, we examined the role of this molecule in the host defense to Cryptococcus neoformans, an opportunistic fungal pathogen in AIDS patients. There was no significant difference in the clinical course and cytokine production between dectin-1 gene-deficient and control mice. These results indicate that dectin-1 is not likely essential for the development of host protective responses to C. neoformans.",

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author = "Kiwamu Nakamura and Takeshi Kinjo and Shinobu Saijo and Akiko Miyazato and Yoshiyuki Adachi and Naohito Ohno and Jiro Fujita and Mitsuo Kaku and Yoichiro Iwakura and Kazuyoshi Kawakami",

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AU - Adachi, Yoshiyuki

AU - Ohno, Naohito

AU - Fujita, Jiro

AU - Kaku, Mitsuo

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AU - Kawakami, Kazuyoshi

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KW - Dectin-1

KW - Dendritic cells

KW - Host defense

KW - IL-12

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Dectin-1 is not required for the host defense to Cryptococcus neoformans

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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