Decreased lipopolysaccharide Content and Enhanced Susceptibility of Leptospiras to Serum Leptospiricidal Action and Phagocytosis After Treatment with Diphenylamine

Emiko Isogai, Hiroshi Isogai, Nobuyoshi Ito

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Growth of leptospiras in the presence of diphenylamine (DPA) caused a decrease in the content of leptospiral lipopolysaccharide (LPS). In association with this decrease of LPS, leptospiras became susceptible to anti-leptospiral action of normal rabbit serum (NRS), leptospiricidal action of antibody and complement, and killing by phagocytes. DPA-treated leptospiras were eliminated rapidly from the blood of infected mice and could not grow in the animals.

Original languageEnglish
Pages (from-to)438-447
Number of pages10
JournalZentralblatt fur Bakteriologie Mikrobiologie und Hygiene - Abt. 1 Orig. A
Volume262
Issue number4
DOIs
Publication statusPublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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