Decreased level of light-induced Fos expression in the suprachiasmatic nucleus of diabetic rats

Shiro Yamanouchi; Takao Shimazoe; Seiko Nagata; Takahiro Moriya; Miyuki Maetani; Shigenobu Shibata; Shigenori Watanabe; Kyoko Miyasaka; Akira Kono; Akihiro Funakoshi

doi:10.1016/S0304-3940(97)00324-8

Decreased level of light-induced Fos expression in the suprachiasmatic nucleus of diabetic rats

Shiro Yamanouchi, Takao Shimazoe, Seiko Nagata, Takahiro Moriya, Miyuki Maetani, Shigenobu Shibata, Shigenori Watanabe, Kyoko Miyasaka, Akira Kono, Akihiro Funakoshi

PHA - Pharmacy

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

We assessed light-induced Fos-immunoreactive cells in the suprachiasmatic nucleus of diabetic rats. The number of Fos-immunoreactive cells significantly decreased in diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats as compared with control Long-Evans Tokushima Otsuka (LETO) rats. In contrast there was no decrease in the number of Fos-immunoreactive cells in young OLETF rats which have not yet developed diabetes. Two months after the administration of streptozotocin (STZ) to Wistar rats, the number of Fos-immunoreactive cells significantly decreased, although 1 week after the administration of STZ, the number had not yet changed in these STZ- induced diabetic rats. These results suggest that chronic diabetic (hyperglycemic) conditions may affect the light entraining responses in the suprachiasmatic nucleus (SCN).

Original language	English
Pages (from-to)	103-106
Number of pages	4
Journal	Neuroscience Letters
Volume	227
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3940(97)00324-8
Publication status	Published - 1997 May 16

Keywords

Circadian rhythm
Diabetes
Fos
Otsuka Long-Evans Tokushima Fatty rats
Streptozotocin
Suprachiasmatic nucleus

ASJC Scopus subject areas

Neuroscience(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0304-3940(97)00324-8

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title = "Decreased level of light-induced Fos expression in the suprachiasmatic nucleus of diabetic rats",

abstract = "We assessed light-induced Fos-immunoreactive cells in the suprachiasmatic nucleus of diabetic rats. The number of Fos-immunoreactive cells significantly decreased in diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats as compared with control Long-Evans Tokushima Otsuka (LETO) rats. In contrast there was no decrease in the number of Fos-immunoreactive cells in young OLETF rats which have not yet developed diabetes. Two months after the administration of streptozotocin (STZ) to Wistar rats, the number of Fos-immunoreactive cells significantly decreased, although 1 week after the administration of STZ, the number had not yet changed in these STZ- induced diabetic rats. These results suggest that chronic diabetic (hyperglycemic) conditions may affect the light entraining responses in the suprachiasmatic nucleus (SCN).",

keywords = "Circadian rhythm, Diabetes, Fos, Otsuka Long-Evans Tokushima Fatty rats, Streptozotocin, Suprachiasmatic nucleus",

author = "Shiro Yamanouchi and Takao Shimazoe and Seiko Nagata and Takahiro Moriya and Miyuki Maetani and Shigenobu Shibata and Shigenori Watanabe and Kyoko Miyasaka and Akira Kono and Akihiro Funakoshi",

year = "1997",

month = may,

day = "16",

doi = "10.1016/S0304-3940(97)00324-8",

language = "English",

volume = "227",

pages = "103--106",

journal = "Neuroscience Letters",

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TY - JOUR

T1 - Decreased level of light-induced Fos expression in the suprachiasmatic nucleus of diabetic rats

AU - Yamanouchi, Shiro

AU - Shimazoe, Takao

AU - Nagata, Seiko

AU - Moriya, Takahiro

AU - Maetani, Miyuki

AU - Shibata, Shigenobu

AU - Watanabe, Shigenori

AU - Miyasaka, Kyoko

AU - Kono, Akira

AU - Funakoshi, Akihiro

PY - 1997/5/16

Y1 - 1997/5/16

N2 - We assessed light-induced Fos-immunoreactive cells in the suprachiasmatic nucleus of diabetic rats. The number of Fos-immunoreactive cells significantly decreased in diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats as compared with control Long-Evans Tokushima Otsuka (LETO) rats. In contrast there was no decrease in the number of Fos-immunoreactive cells in young OLETF rats which have not yet developed diabetes. Two months after the administration of streptozotocin (STZ) to Wistar rats, the number of Fos-immunoreactive cells significantly decreased, although 1 week after the administration of STZ, the number had not yet changed in these STZ- induced diabetic rats. These results suggest that chronic diabetic (hyperglycemic) conditions may affect the light entraining responses in the suprachiasmatic nucleus (SCN).

AB - We assessed light-induced Fos-immunoreactive cells in the suprachiasmatic nucleus of diabetic rats. The number of Fos-immunoreactive cells significantly decreased in diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats as compared with control Long-Evans Tokushima Otsuka (LETO) rats. In contrast there was no decrease in the number of Fos-immunoreactive cells in young OLETF rats which have not yet developed diabetes. Two months after the administration of streptozotocin (STZ) to Wistar rats, the number of Fos-immunoreactive cells significantly decreased, although 1 week after the administration of STZ, the number had not yet changed in these STZ- induced diabetic rats. These results suggest that chronic diabetic (hyperglycemic) conditions may affect the light entraining responses in the suprachiasmatic nucleus (SCN).

KW - Circadian rhythm

KW - Diabetes

KW - Fos

KW - Otsuka Long-Evans Tokushima Fatty rats

KW - Streptozotocin

KW - Suprachiasmatic nucleus

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DO - 10.1016/S0304-3940(97)00324-8

M3 - Article

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AN - SCOPUS:0030985958

SN - 0304-3940

VL - 227

SP - 103

EP - 106

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2

ER -

Decreased level of light-induced Fos expression in the suprachiasmatic nucleus of diabetic rats

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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