Decreased keratinocyte motility in skin wound on mice lacking the epidermal fatty acid binding protein gene

Yoshiyuki Kusakari, Eisaku Ogawa, Yuji Owada, Noriko Kitanaka, Hiroshi Watanabe, Michiyo Kimura, Hachiro Tagami, Hisatake Kondo, Setsuya Aiba, Ryuhei Okuyama

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Fatty acids are shown to be important in various skin functions. Fatty acid binding protein (FABP) is postulated to serve as a lipid shuttle, solubilizing hydrophobic fatty acids and delivering them to the appropriate metabolic system. Among the FABP family proteins, epidermal-type FABP (E-FABP) is solely expressed in keratinocyte but its specific role in skin is not yet fully established. We found an elevated expression of E-FABP in regenerative keratinocytes of healing wounds. However, E-FABP null mice showed no marked differences compared to wild type mice in the process of wound closure, in vivo. On the other hand, in keratinocyte culture, E-FABP gene disruption decreased the cell motility, but did not affect the cell proliferation. E-FABP deletion may be compensated for in vivo by the microenvironment comprised of various cells such as fibroblasts and endothelial cells around the wound. Our analyses suggest that the E-FABP elevation may be necessary for the activation of cell motility within regenerative epidermis during wound healing.

Original languageEnglish
Pages (from-to)183-188
Number of pages6
JournalMolecular and Cellular Biochemistry
Volume284
Issue number1-2
DOIs
Publication statusPublished - 2006 Mar

Keywords

  • Cell motility
  • FABP
  • Fatty acid
  • Keratinocyte
  • Regeneration
  • Wound healing

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

Fingerprint Dive into the research topics of 'Decreased keratinocyte motility in skin wound on mice lacking the epidermal fatty acid binding protein gene'. Together they form a unique fingerprint.

Cite this