Decreased incidence of thymic lymphoma in AKR mice as a result of chronic, fractionated low-dose total-body X irradiation

Keiichiro Ishii, Yoshio Hosoi, Shougo Yamada, Tetsuya Ono, Kiyohiko Sakamoto

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59 Citations (Scopus)

Abstract

We have investigated whether low-dose total-body X irradiation could suppress the development of lymphoma in AKR mice. Male mice were irradiated with 5 cGy three times a week or 15 cGy two times a week from 11 weeks of age for 40 weeks. The incidences of lymphoma were 80.5% in sham-irradiated mice, 67.5% in mice irradiated with 5 cGy three times a week and 48.6% in mice irradiated with 15 cGy twice a week. Incidence of lymphoma was significantly reduced by irradiation with 15 cGy twice a week (P = 0.006). The mean survival time was significantly prolonged from 283 ± 3 days in control mice to 316 ± 10 days in mice irradiated with 15 cGy twice a week (P = 0.008) and to 309 ± 14 days in mice irradiated with 5 cGy three times a week (P = 0.040). Because about 80% of male AKR mice die of lymphoma, it is likely that the prolonged life span observed in the irradiated mice is due to the reduced incidence of lymphoma.

Original languageEnglish
Pages (from-to)582-585
Number of pages4
JournalRadiation Research
Volume146
Issue number5
DOIs
Publication statusPublished - 1996 Nov

ASJC Scopus subject areas

  • Biophysics
  • Radiation
  • Radiology Nuclear Medicine and imaging

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