Decreased expression of neurotrophin-3 mRNA in the rat hippocampus following transient forebrain ischemia

Atsushi Takeda, Hiroshi Onodera, Yasundo Yamasaki, Katsutoshi Furukawa, Kyuya Kogure, Masuo Obinata, Shigeki Shibahara

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)

Abstract

The expression profile of neurotrophin-3 (NT-3) mRNA in the rat hippocampus after forebrain ischemia was investigated by Northern blot and S1 nuclease protection analyses. The NT-3 transcripts in the hippocampus immediately decreased after ischemic insult, became undetectable within 3 h and remained at undetectable levels for at least 7 days. In contrast, the expression of c-fos and c-jun mRNA transiently increased both in the cerebral cortex and in the hippocampus. These results suggest that brain ischemia triggers dynamic changes in gene expression including a neurotrophic factor, which may cause functional and/or morphological changes of the neuronal network.

Original languageEnglish
Pages (from-to)177-180
Number of pages4
JournalBrain research
Volume569
Issue number1
DOIs
Publication statusPublished - 1992 Jan 8

Keywords

  • Cerebral ischemia
  • Gene expression
  • Neuronal death
  • Neurotrophic factor
  • c-fos
  • c-jun

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Fingerprint

Dive into the research topics of 'Decreased expression of neurotrophin-3 mRNA in the rat hippocampus following transient forebrain ischemia'. Together they form a unique fingerprint.

Cite this