Decreased expression of c-myc family genes in thymuses from myasthenia gravis patients

T. Nagata, H. Onodera, M. Ohuchi, Y. Suzuki, H. Tago, K. Fujihara, N. Ishii, K. Sugamura, Y. Shoji, M. Handa, K. Tabayashi, Y. Itoyama

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

The thymus is a critical organ for the elimination of autoreactive T cells by apoptosis. We studied the expression of apoptosis-associated genes, bcl-xL, bad, caspase-3, and c-myc family genes in myasthenia gravis (MG) thymuses. We observed that the mRNA levels of myc family genes, c-myc and max, were markedly reduced in MG thymuses. These results indicate that c-myc-mediated signaling is abnormal in MG thymuses. The levels of molecules whose expressions are associated with myc, such as STAM, prothymosin-alpha, and NFkappaB, were also analyzed.

Original languageEnglish
Pages (from-to)199-202
Number of pages4
JournalJournal of Neuroimmunology
Volume115
Issue number1-2
DOIs
Publication statusPublished - 2001 Apr 2

Keywords

  • Apoptosis
  • Myasthenia gravis
  • NFkappaB
  • STAM
  • Thymus
  • c-myc

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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