TY - JOUR
T1 - Decrease in Reduced-Form Albumin Among Chronic Kidney Disease Patients
T2 - New Insights in Cardiovascular Complications
AU - Terawaki, Hiroyuki
AU - Era, Seiichi
AU - Nakayama, Masaaki
AU - Hosoya, Tatsuo
PY - 2011/4
Y1 - 2011/4
N2 - From the perspective of free cysteine residue (Cys-34), human serum albumin (HSA) comprises a mixture of human mercaptoalbumin (HMA), in which the Cys-34 is not oxidized, human non-mercaptoalbumin (HNA)-1, which has a disulfide bond that can be reversibly oxidized, mainly by cysteine, and HNA-2, which is strongly oxidized to form sulfinic (-SO2H) or sulfonic (-SO3H) species. We have developed a convenient high-performance liquid chromatographic (HPLC) system for the clear separation of HSA into HMA, HNA-1 and HNA-2, and we have studied the dynamic changes of HSA-redox under various states of chronic kidney disease, in both a clinical and an experimental setting. In this article, we discuss the relationship between HSA-redox (especially the decrease of the reduced form), dialyzable uremic toxins and incident cardiovascular disease based on our recent investigations.
AB - From the perspective of free cysteine residue (Cys-34), human serum albumin (HSA) comprises a mixture of human mercaptoalbumin (HMA), in which the Cys-34 is not oxidized, human non-mercaptoalbumin (HNA)-1, which has a disulfide bond that can be reversibly oxidized, mainly by cysteine, and HNA-2, which is strongly oxidized to form sulfinic (-SO2H) or sulfonic (-SO3H) species. We have developed a convenient high-performance liquid chromatographic (HPLC) system for the clear separation of HSA into HMA, HNA-1 and HNA-2, and we have studied the dynamic changes of HSA-redox under various states of chronic kidney disease, in both a clinical and an experimental setting. In this article, we discuss the relationship between HSA-redox (especially the decrease of the reduced form), dialyzable uremic toxins and incident cardiovascular disease based on our recent investigations.
KW - Cardiovascular disease
KW - Chronic kidney disease
KW - Oxidative stress
KW - Redox state of albumin
UR - http://www.scopus.com/inward/record.url?scp=79953041507&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79953041507&partnerID=8YFLogxK
U2 - 10.1111/j.1744-9987.2010.00889.x
DO - 10.1111/j.1744-9987.2010.00889.x
M3 - Article
C2 - 21426508
AN - SCOPUS:79953041507
VL - 15
SP - 156
EP - 160
JO - Therapeutic Apheresis and Dialysis
JF - Therapeutic Apheresis and Dialysis
SN - 1744-9979
IS - 2
ER -
