Decrease in cerebellin and corticotropin-releasing hormone in the cerebellum of olivopontocerebellar atrophy and Shy-Drager syndrome

Yasuji Mizuno, Kazuhiro Takahashi, Kazuhito Totsune, Makoto Ohneda, Hidehiko Konno, Osamu Murakami, Fumitoshi Satoh, Masahiko Sone, Sadao Takase, Yasuto Itoyama, Toraichi Mouri

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Four neuropeptides; cerebellin, corticotropin-releasing hormone (CRH), neuropeptide Y and somatostatin were studied by radioimmunoassay in the postmortem human brains obtained from three patients with olivopontocerebellar atrophy (OPCA) and one with Shy-Drager syndrome. Significant decreases in cerebellin and CRH concentrations were found in the cerebellar hemisphere of these diseases compared with controls. These findings suggest important pathophysiological roles of cerebellin and CRH in these cerebellar diseases. Such significant decreases were not found in neuropeptide Y and somatostatin.

Original languageEnglish
Pages (from-to)115-118
Number of pages4
JournalBrain research
Volume686
Issue number1
DOIs
Publication statusPublished - 1995 Jul 17

Keywords

  • Cerebellin
  • Cerebellum
  • Corticotropin-releasing hormone
  • Multiple system atrophy
  • Neuropeptide
  • Olivopontocerebellar atrophy
  • Radioimmunoassay
  • Shy-Drager syndrome

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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