Decline in estimated glomerular filtration rate is associated with risk of end-stage renal disease in type 2 diabetes with macroalbuminuria: An observational study from JDNCS

Research Group of Diabetic Nephropathy the Ministry of Health, Labour Welfare of Japan and Japan Agency for Medical Research and Development

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6 Citations (Scopus)

Abstract

Background There is increased interest in surrogate endpoints for clinical trials of chronic kidney disease. Methods In this nationwide observational study of 456 patients with type 2 diabetes and clinically suspected diabetic nephropathy followed for a median of 4.2 years, we evaluated the association between estimated glomerular filtration rate (eGFR) and albuminuria at baseline or during follow-up and risk of ESRD. Results Low eGFR (\60 mL/min/1.73 m2) and macroalbuminuria at enrollment were independently associated with risk of ESRD. In patients with macroalbuminuria, both B-50% change and -50 to -30% change in eGFR over 1 and 2 years were predictive of ESRD. The higher cut point (C50% decline in eGFR) was more strongly predictive but less common. Remission of macroalbuminuria to normo-/microalbuminuria at 1 and 2 years was associated with a lower incidence of ESRD than no remission; however, it was not a determinant for ESRD independently of initial eGFR and initial protein-to-crea-tinine ratio. Conclusion These results suggest that a C30% decline in eGFR over 1 or 2 years adds prognostic information about risk for ESRD in patients with type 2 diabetes and macroalbuminuria, supporting the consideration of percentage decline in eGFR as a surrogate endpoint among macroalbuminuric cases in type 2 diabetes. On the other hand, our study suggests that additional analyses on the relationship between remission of macroalbuminuria and risk of ESRD are needed in type 2 diabetes.

Original languageEnglish
Pages (from-to)377-387
Number of pages11
JournalClinical and Experimental Nephrology
Volume22
Issue number2
DOIs
Publication statusPublished - 2018 Jan 1
Externally publishedYes

Keywords

  • Changes in estimated glomerular filtration rate
  • Diabetic nephropathy
  • End-stage renal disease
  • Remission of macroalbuminuria
  • Surrogate endpoints

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)

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