De novo Crohn’s disease following orthotopic liver transplantation: A case report and literature review

Takeo Naito, Hisashi Shiga, Katsuya Endo, Masatake Kuroha, Yoichi Kakuta, Yoshitaka Kinouchi, Tooru Shimosegawa

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

The development of de novo Crohn’s disease (CD) after orthotopic liver transplantation (OLT) is rare, possibly due to the continuous use of immunosuppressive treatment. Although several cases of CD following OLT have been reported worldwide, there are currently so such cases in Japan. We herein report the case of a patient who newly developed CD after undergoing OLT for congenital biliary atresia. The patient subsequently underwent ileocecal resection and has since maintained clinical remission. This is the first report of this condition in Japan. We also review the literature concerning cases of de novo inflammatory bowel disease (IBD) developing after OLT, and discuss the causes of and role of immunosuppressive agents in treating IBD.

Original languageEnglish
Pages (from-to)199-204
Number of pages6
JournalInternal Medicine
Volume54
Issue number2
DOIs
Publication statusPublished - 2015 Jan 15

Keywords

  • Crohn’s disease
  • De novo Crohn’s disease
  • Immunosuppressive Agents
  • Orthotopic liver transplantation

ASJC Scopus subject areas

  • Internal Medicine

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