Daily Variation of Blood Pressure in Patients with Cushing's Syndrome

Yutaka Imai, Keishi Abe, Shuichi Sasaki, Naoyoshi Minami, Minoru Nihei, Masanori Munakata, Kaoru Yoshinaga, Hiroshi Sekino

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


The circadian rhythm of blood pressure (BP) was compared between patients with Cushing's syndrome and those with essential hypertension. In patients with essential hypertension, clear nocturnal falls in systolic and diastolic BP and heart rate (HR) were observed, and there was a positive correlation between HR and systolic or diastolic BP. On the other hand, in patients with Cushing's syndrome, there was no nocturnal fall in BP and instead a rise in some cases. In all cases with Cushing's syndrome there was a nocturnal fall in HR, and consequently no significant correlation between HR and BP in these patients. The present results imply that the normal circadian rhythm of blood pressure may be regulated at least in part by the hypothalamo-pituitary-adrenal system.

Original languageEnglish
Pages (from-to)67-74
Number of pages8
Journalthe tohoku journal of experimental medicine
Issue number1
Publication statusPublished - 1987
Externally publishedYes


  • Cushing's syndrome
  • ambulatory blood pressure monitoring
  • blood pressure
  • circadian rhythm
  • heart rate

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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