TY - JOUR
T1 - Dab1 contributes differently to the morphogenesis of the hippocampal subdivisions
AU - Blume, Marissa
AU - Inoguchi, Fuduki
AU - Sugiyama, Taku
AU - Owada, Yuji
AU - Osumi, Noriko
AU - Aimi, Yoshinari
AU - Taki, Kosuke
AU - Katsuyama, Yu
N1 - Funding Information:
MB received a mobility grant from the Education, Audiovisual and Culture Executive Agency, Tempus & Bilateral Cooperation with Industrialised Countries, Grant 2013 – 3396/001 – 001 entitled “Joint Degree Project – Edu-Neuro EU-JP: Double European-Japan Master Degree in Neuroscience “. YK was supported by a research grant (Kiban C, No. 26440112) from the Ministry of Education, Science, Sports and Culture of Japan (MEXT). We acknowledge the support of the Biomedical Research Core of Tohoku University Graduate School of Medicine, and Central Research Laboratory Shiga University of Medical Science.
Publisher Copyright:
© 2017 Japanese Society of Developmental Biologists
PY - 2017/10
Y1 - 2017/10
N2 - The hippocampal formation (HF) is morphologically and functionally distinguishable into the subdivisions, such as the dentate gyrus (DG), subiculum, and Ammon's horn. The Ammon's horn is further divided into the CA (Cornu Ammonis)1, CA2, and CA3. The Reelin-Dab1 signal is essential for the morphogenesis of the mammalian brain. In the neocortex of Reelin-Dab1 signal mutants the laminar pattern of the neurons is disrupted along the radial axis. Morphological abnormalities in the HF of the Reelin-Dab1 mutants were known, but how these abnormalities appear during development had not been extensively studied. We examined the morphology of the well-developed Dab1 deficient HF by staining with a silver impregnation method in this report, and found that disruption of lamination in the CA1, CA3, and DG was different. Abnormalities observed in the development of Dab1 deficient CA1 were similar to those reported in the neocortical development, while Dab1 deficient CA3 neuronal progenitors radially spreaded beyond presumptive pyramidal layer. The intermediate progenitor cells ectopically located in the Dab1 deficient DG, but neurogenesis was normal in the CA1 and CA3. These observations suggest that the morphogenesis in these HF subdivisions employs different developmental mechanisms involving Dab1 function.
AB - The hippocampal formation (HF) is morphologically and functionally distinguishable into the subdivisions, such as the dentate gyrus (DG), subiculum, and Ammon's horn. The Ammon's horn is further divided into the CA (Cornu Ammonis)1, CA2, and CA3. The Reelin-Dab1 signal is essential for the morphogenesis of the mammalian brain. In the neocortex of Reelin-Dab1 signal mutants the laminar pattern of the neurons is disrupted along the radial axis. Morphological abnormalities in the HF of the Reelin-Dab1 mutants were known, but how these abnormalities appear during development had not been extensively studied. We examined the morphology of the well-developed Dab1 deficient HF by staining with a silver impregnation method in this report, and found that disruption of lamination in the CA1, CA3, and DG was different. Abnormalities observed in the development of Dab1 deficient CA1 were similar to those reported in the neocortical development, while Dab1 deficient CA3 neuronal progenitors radially spreaded beyond presumptive pyramidal layer. The intermediate progenitor cells ectopically located in the Dab1 deficient DG, but neurogenesis was normal in the CA1 and CA3. These observations suggest that the morphogenesis in these HF subdivisions employs different developmental mechanisms involving Dab1 function.
KW - Dab1
KW - expression of transcription factors
KW - hippocampal subdivisions
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U2 - 10.1111/dgd.12393
DO - 10.1111/dgd.12393
M3 - Article
C2 - 28945921
AN - SCOPUS:85031493757
VL - 59
SP - 657
EP - 673
JO - Development Growth and Differentiation
JF - Development Growth and Differentiation
SN - 0012-1592
IS - 8
ER -