Cytotoxicity of Pure Nanodrugs of SN-38 and Podophyllotoxin Dimers in Human Cancer HepG2, KPL-4, and MCF-7 Cells

Yoshitaka Koseki, Yoshikazu Ikuta, Tatsuya Murakami, Tsunenobu Onodera, Hidetoshi Oikawa, Liman Cong, Hiroshi Tada, Kohsuke Gonda, Noriaki Ohuchi, Hitoshi Kasai

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Pure nanodrugs (PNDs) is a newly designed drug materials, which is a carrier-free drug nanoparticles fabricated by the reprecipitation method. In the present study, the cytotoxicity of PNDs consisting of SN-38 dimer and podophyllotoxin dimer with size in the range 30-50 nm was evaluated in human cancer HepG2, KPL-4, and MCF-7 cells. It was observed that the cytotoxicities of PNDs were changed depending on the type of cells. In addition, PNDs coated with polysorbate 80 showed higher activity than free PNDs, which suggests that the surface state of PNDs was the one of the important factors to affect cytotoxicity.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalMolecular crystals and liquid crystals
Volume622
Issue number1
DOIs
Publication statusPublished - 2015 Nov 22

Keywords

  • Cytotoxicity
  • Podophyllotoxin (PPT)
  • Pure nanodrugs (PNDs)
  • Reprecipitation method
  • SN-38

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

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