Cytotoxic flavonoids from the flowers of Achillea millefolium

Chang Hong Huo, Yong Li, Man Li Zhang, Yu Fang Wang, Qing Zhang, Fang Qin, Qing Wen Shi, Hiromasa Kiyota

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A new natural product, 8,8'-bi-3-O-methylquercetin (9), and eight known flavonoids were isolated from the flowers of Achillea millefolium. Their structures were established on the basis of spectral evidence. All the spectral data of these compounds were reassigned after interpretation of their 2D NMR spectroscopic data. Compounds 2, 5, and 7 exhibited antiproliferative activity against human breast cancer cell line MCF7WT. In addition, 2 and 5 showed antiproliferative activity against human prostatic cancer cell line PC-3, while the other compounds did not show inhibitory effects in two human tumor cell lines tested.

Original languageEnglish
Pages (from-to)958-962
Number of pages5
JournalChemistry of Natural Compounds
Volume48
Issue number6
DOIs
Publication statusPublished - 2013 Jan 1

Keywords

  • Achillea millefolium
  • Compositae
  • antiproliferative activity
  • flavonoids

ASJC Scopus subject areas

  • Plant Science

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