Cytotoxic flavonoids from the flowers of Achillea millefolium

Chang Hong Huo, Yong Li, Man Li Zhang, Yu Fang Wang, Qing Zhang, Fang Qin, Qing Wen Shi, Hiromasa Kiyota

    Research output: Contribution to journalArticlepeer-review

    25 Citations (Scopus)

    Abstract

    A new natural product, 8,8'-bi-3-O-methylquercetin (9), and eight known flavonoids were isolated from the flowers of Achillea millefolium. Their structures were established on the basis of spectral evidence. All the spectral data of these compounds were reassigned after interpretation of their 2D NMR spectroscopic data. Compounds 2, 5, and 7 exhibited antiproliferative activity against human breast cancer cell line MCF7WT. In addition, 2 and 5 showed antiproliferative activity against human prostatic cancer cell line PC-3, while the other compounds did not show inhibitory effects in two human tumor cell lines tested.

    Original languageEnglish
    Pages (from-to)958-962
    Number of pages5
    JournalChemistry of Natural Compounds
    Volume48
    Issue number6
    DOIs
    Publication statusPublished - 2013 Jan

    Keywords

    • Achillea millefolium
    • Compositae
    • antiproliferative activity
    • flavonoids

    ASJC Scopus subject areas

    • Plant Science

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