Cytoskeletal dynamics during mammalian gametegenesis and fertilization: Implications for human reproduction

Yukihiro Terada, Yuki Morito, Masahito Tachibana, Junko Morita, So Ichi Nakamura, Takashi Murakami, Nobuo Yaegashi, Kunihiro Okamura

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

From gamete to neonate, human fertilization is a series of cell motilities (motion and morphological changes). Cytoskeletons play a role in cell motility as they work as a field worker in the cell. The present study is a review of dynamic motility of cytoskeletons (microfilaments and microtubules) during mammalian gamategenesis and fertilization. Dynamic and proper organization of cytoskeletons is crucial for the completion of oocyte maturation and spermatogenesis. By intracytoplasmic sperm injection, some difficulties in fertilization by sperm entry into the egg cytoplasm are overcome. However, the goal of fertilization is the union of the male and female genome, and sperm incorporation into an oocyte is nothing but the beginning of fertilization. Sperm centrosomal function, which introduces microtubule organization and promotes pronuclear apposition and first mitotic spindle formation, plays the leading role in the 'motility' of post-intracytoplasmic sperm injection events in fertilization. The present review introduces novel challenges in functional assessment of the human sperm centrosome. Furthermore, microtubule organization during development without the sperm centrosome (e.g. parthenogenesis) is mentioned.

Original languageEnglish
Pages (from-to)179-187
Number of pages9
JournalReproductive Medicine and Biology
Volume4
Issue number3
DOIs
Publication statusPublished - 2005 Sep

Keywords

  • Assisted reproductive techniques
  • Cytoskeleton
  • Fertilization
  • Gametegenesis
  • Sperm centrosome

ASJC Scopus subject areas

  • Reproductive Medicine
  • Cell Biology

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