Cytokines in the serum and brain in mice infected with distinct species of Lyme disease Borrelia

Emiko Isogai, Hiroshi Isogai, Koichi Kimura, Syunji Hayashi, Toru Kubota, Takeshi Nishikawa, Akio Nakane, Nobuhiro Fujii

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


This study describes the detection of cytokines, interleukin-1 alpha (IL-1α), tumor necrosis-factor alpha (TNFα) and interleukin-6 (IL-6) in the serum and brain homogenates of susceptible and resistant strains of mice infected with distinct species/strains of Borrelia. Significant elevation of inflammatory cytokines was found in the sera of susceptible C3H/HeN mice but not in the sera of resistant BALB/c mice on days 7 and 45 after inoculation. Brain cytokines were observed in C3H/HeN mice infected with B. garinii and B. afzelii and the production was associated with the presence of spirochetes. B. japonica was the only exception in disease-susceptibility and cytokine production of mice. These results suggest that there are differences in pathogenic potential amongst Borrelia strains, and that the susceptible mice demonstrate a stronger cytokine response and greater frequency of recovery of Borrelia from the brain than do the resistant mice.

Original languageEnglish
Pages (from-to)413-419
Number of pages7
JournalMicrobial Pathogenesis
Issue number6
Publication statusPublished - 1996 Dec
Externally publishedYes


  • Borrelia burgdorferi
  • Brain
  • Inflammatory cytokines
  • Lyme disease
  • Mouse model

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases


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