Cytokine stimulated endothelin release from endothelial cells

Sandip M. Kanse, Kazuhiro Takahashi, Hing Chung Lam, Andrew Rees, John B. Warren, Massimo Porta, Pia Molinatti, Mohammad Ghatei, Stephen R. Bloom

Research output: Contribution to journalArticlepeer-review

88 Citations (Scopus)

Abstract

Endothelin release from bovine endothelial cells of the aorta, pulmonary artery, and retinal microvessels was measured in response to various cytokines. Transforming growth factorβ (0.05-5 ng/ml) was found to be a potent stimulator (3-4 fold increase) of endothelin secretion in all three cell types. Tumour necrosis factorα (0.1-10 ng/ml) and interferonγ (8-800 U/ml) had a small (1.5-2 fold increase) but significant effect on endothelin secretion from endothelial cells of large vessels but not the retinal microvessels. Interleukin-1β, Interleukin-6 and interleukin-8 at various doses did not affect endothelin secretion. These effects were observed at various time points from 6-24 hrs and indicate that of the cytokines tested, only transforming growth factor β has a potent effect on endothelin release from endothelial cells of different organs.

Original languageEnglish
Pages (from-to)1379-1384
Number of pages6
JournalLife Sciences
Volume48
Issue number14
DOIs
Publication statusPublished - 1991
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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