Cytokine stimulated endothelin release from endothelial cells

Sandip M. Kanse; Kazuhiro Takahashi; Hing Chung Lam; Andrew Rees; John B. Warren; Massimo Porta; Pia Molinatti; Mohammad Ghatei; Stephen R. Bloom

doi:10.1016/0024-3205(91)90434-D

Cytokine stimulated endothelin release from endothelial cells

Sandip M. Kanse, Kazuhiro Takahashi, Hing Chung Lam, Andrew Rees, John B. Warren, Massimo Porta, Pia Molinatti, Mohammad Ghatei, Stephen R. Bloom

Research output: Contribution to journal › Article › peer-review

89 Citations (Scopus)

Abstract

Endothelin release from bovine endothelial cells of the aorta, pulmonary artery, and retinal microvessels was measured in response to various cytokines. Transforming growth factorβ (0.05-5 ng/ml) was found to be a potent stimulator (3-4 fold increase) of endothelin secretion in all three cell types. Tumour necrosis factorα (0.1-10 ng/ml) and interferonγ (8-800 U/ml) had a small (1.5-2 fold increase) but significant effect on endothelin secretion from endothelial cells of large vessels but not the retinal microvessels. Interleukin-1β, Interleukin-6 and interleukin-8 at various doses did not affect endothelin secretion. These effects were observed at various time points from 6-24 hrs and indicate that of the cytokines tested, only transforming growth factor β has a potent effect on endothelin release from endothelial cells of different organs.

Original language	English
Pages (from-to)	1379-1384
Number of pages	6
Journal	Life Sciences
Volume	48
Issue number	14
DOIs	https://doi.org/10.1016/0024-3205(91)90434-D
Publication status	Published - 1991
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(91)90434-D

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title = "Cytokine stimulated endothelin release from endothelial cells",

abstract = "Endothelin release from bovine endothelial cells of the aorta, pulmonary artery, and retinal microvessels was measured in response to various cytokines. Transforming growth factorβ (0.05-5 ng/ml) was found to be a potent stimulator (3-4 fold increase) of endothelin secretion in all three cell types. Tumour necrosis factorα (0.1-10 ng/ml) and interferonγ (8-800 U/ml) had a small (1.5-2 fold increase) but significant effect on endothelin secretion from endothelial cells of large vessels but not the retinal microvessels. Interleukin-1β, Interleukin-6 and interleukin-8 at various doses did not affect endothelin secretion. These effects were observed at various time points from 6-24 hrs and indicate that of the cytokines tested, only transforming growth factor β has a potent effect on endothelin release from endothelial cells of different organs.",

author = "Kanse, {Sandip M.} and Kazuhiro Takahashi and Lam, {Hing Chung} and Andrew Rees and Warren, {John B.} and Massimo Porta and Pia Molinatti and Mohammad Ghatei and Bloom, {Stephen R.}",

year = "1991",

doi = "10.1016/0024-3205(91)90434-D",

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AU - Kanse, Sandip M.

AU - Takahashi, Kazuhiro

AU - Lam, Hing Chung

AU - Rees, Andrew

AU - Warren, John B.

AU - Porta, Massimo

AU - Molinatti, Pia

AU - Ghatei, Mohammad

AU - Bloom, Stephen R.

PY - 1991

Y1 - 1991

N2 - Endothelin release from bovine endothelial cells of the aorta, pulmonary artery, and retinal microvessels was measured in response to various cytokines. Transforming growth factorβ (0.05-5 ng/ml) was found to be a potent stimulator (3-4 fold increase) of endothelin secretion in all three cell types. Tumour necrosis factorα (0.1-10 ng/ml) and interferonγ (8-800 U/ml) had a small (1.5-2 fold increase) but significant effect on endothelin secretion from endothelial cells of large vessels but not the retinal microvessels. Interleukin-1β, Interleukin-6 and interleukin-8 at various doses did not affect endothelin secretion. These effects were observed at various time points from 6-24 hrs and indicate that of the cytokines tested, only transforming growth factor β has a potent effect on endothelin release from endothelial cells of different organs.

AB - Endothelin release from bovine endothelial cells of the aorta, pulmonary artery, and retinal microvessels was measured in response to various cytokines. Transforming growth factorβ (0.05-5 ng/ml) was found to be a potent stimulator (3-4 fold increase) of endothelin secretion in all three cell types. Tumour necrosis factorα (0.1-10 ng/ml) and interferonγ (8-800 U/ml) had a small (1.5-2 fold increase) but significant effect on endothelin secretion from endothelial cells of large vessels but not the retinal microvessels. Interleukin-1β, Interleukin-6 and interleukin-8 at various doses did not affect endothelin secretion. These effects were observed at various time points from 6-24 hrs and indicate that of the cytokines tested, only transforming growth factor β has a potent effect on endothelin release from endothelial cells of different organs.

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SN - 0024-3205

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Cytokine stimulated endothelin release from endothelial cells

Abstract

ASJC Scopus subject areas

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