Cysteine-derived organocatalyst in a highly enantioselective intramolecular Michael reaction

Yujiro Hayashi, Hiroaki Gotoh, Tomohiro Tamura, Hirofumi Yamaguchi, Ryouhei Masui, Mitsuru Shoji

Research output: Contribution to journalArticlepeer-review

197 Citations (Scopus)


Asymmetric intramolecular Michael reaction catalyzed by an organocatalyst derived from cysteine has been developed for the synthesis of chiral bicyclo[4.3.0]nonene and cis-disubstituted cyclopentane skeletons with a creation of three or two contiguous chiral centers in good yield with high diastereo- and excellent enantioselectivities.

Original languageEnglish
Pages (from-to)16028-16029
Number of pages2
JournalJournal of the American Chemical Society
Issue number46
Publication statusPublished - 2005 Nov 23
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry


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