Cyclophilin A: Promising new target in cardiovascular therapy

Kimio Satoh; Hiroaki Shimokawa; Bradford C. Berk

doi:10.1253/circj.CJ-10-0904

Cyclophilin A: Promising new target in cardiovascular therapy

Kimio Satoh, Hiroaki Shimokawa, Bradford C. Berk

Research output: Contribution to journal › Review article › peer-review

77 Citations (Scopus)

Abstract

Cyclophilin A (CyPA) has been studied as a multifunctional protein that is upregulated in a variety of inflammatory conditions, such as rheumatoid arthritis, autoimmune disease, and cancer. CyPA has been classified as an immunophilin and has a variety of intracellular functions, including intracellular signaling, protein trafficking, and the regulation of other proteins activity. Besides its intracellular functions, CyPA is a secreted molecule that has a physiological and pathological role in cardiovascular diseases, making it a potential biomarker and mediator in cardiovascular diseases, such as vascular stenosis, atherosclerosis, and abdominal aortic aneurysms.

Original language	English
Pages (from-to)	2249-2256
Number of pages	8
Journal	Circulation Journal
Volume	74
Issue number	11
DOIs	https://doi.org/10.1253/circj.CJ-10-0904
Publication status	Published - 2010 Nov

Keywords

Immunophilin
Matrix metalloproteinase
Reactive oxygen species
Remodeling
Vasculature

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1253/circj.CJ-10-0904

Cite this

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title = "Cyclophilin A: Promising new target in cardiovascular therapy",

abstract = "Cyclophilin A (CyPA) has been studied as a multifunctional protein that is upregulated in a variety of inflammatory conditions, such as rheumatoid arthritis, autoimmune disease, and cancer. CyPA has been classified as an immunophilin and has a variety of intracellular functions, including intracellular signaling, protein trafficking, and the regulation of other proteins activity. Besides its intracellular functions, CyPA is a secreted molecule that has a physiological and pathological role in cardiovascular diseases, making it a potential biomarker and mediator in cardiovascular diseases, such as vascular stenosis, atherosclerosis, and abdominal aortic aneurysms.",

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T2 - Promising new target in cardiovascular therapy

AU - Satoh, Kimio

AU - Shimokawa, Hiroaki

AU - Berk, Bradford C.

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N2 - Cyclophilin A (CyPA) has been studied as a multifunctional protein that is upregulated in a variety of inflammatory conditions, such as rheumatoid arthritis, autoimmune disease, and cancer. CyPA has been classified as an immunophilin and has a variety of intracellular functions, including intracellular signaling, protein trafficking, and the regulation of other proteins activity. Besides its intracellular functions, CyPA is a secreted molecule that has a physiological and pathological role in cardiovascular diseases, making it a potential biomarker and mediator in cardiovascular diseases, such as vascular stenosis, atherosclerosis, and abdominal aortic aneurysms.

AB - Cyclophilin A (CyPA) has been studied as a multifunctional protein that is upregulated in a variety of inflammatory conditions, such as rheumatoid arthritis, autoimmune disease, and cancer. CyPA has been classified as an immunophilin and has a variety of intracellular functions, including intracellular signaling, protein trafficking, and the regulation of other proteins activity. Besides its intracellular functions, CyPA is a secreted molecule that has a physiological and pathological role in cardiovascular diseases, making it a potential biomarker and mediator in cardiovascular diseases, such as vascular stenosis, atherosclerosis, and abdominal aortic aneurysms.

KW - Immunophilin

KW - Matrix metalloproteinase

KW - Reactive oxygen species

KW - Remodeling

KW - Vasculature

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M3 - Review article

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JO - Circulation Journal

JF - Circulation Journal

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Cyclophilin A: Promising new target in cardiovascular therapy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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