Cyclophilin A: Promising new target in cardiovascular therapy

Kimio Satoh, Hiroaki Shimokawa, Bradford C. Berk

Research output: Contribution to journalReview article

72 Citations (Scopus)

Abstract

Cyclophilin A (CyPA) has been studied as a multifunctional protein that is upregulated in a variety of inflammatory conditions, such as rheumatoid arthritis, autoimmune disease, and cancer. CyPA has been classified as an immunophilin and has a variety of intracellular functions, including intracellular signaling, protein trafficking, and the regulation of other proteins activity. Besides its intracellular functions, CyPA is a secreted molecule that has a physiological and pathological role in cardiovascular diseases, making it a potential biomarker and mediator in cardiovascular diseases, such as vascular stenosis, atherosclerosis, and abdominal aortic aneurysms.

Original languageEnglish
Pages (from-to)2249-2256
Number of pages8
JournalCirculation Journal
Volume74
Issue number11
DOIs
Publication statusPublished - 2010 Nov 1

Keywords

  • Immunophilin
  • Matrix metalloproteinase
  • Reactive oxygen species
  • Remodeling
  • Vasculature

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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