TY - JOUR
T1 - Cyclophilin A
T2 - Promising new target in cardiovascular therapy
AU - Satoh, Kimio
AU - Shimokawa, Hiroaki
AU - Berk, Bradford C.
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2010/11
Y1 - 2010/11
N2 - Cyclophilin A (CyPA) has been studied as a multifunctional protein that is upregulated in a variety of inflammatory conditions, such as rheumatoid arthritis, autoimmune disease, and cancer. CyPA has been classified as an immunophilin and has a variety of intracellular functions, including intracellular signaling, protein trafficking, and the regulation of other proteins activity. Besides its intracellular functions, CyPA is a secreted molecule that has a physiological and pathological role in cardiovascular diseases, making it a potential biomarker and mediator in cardiovascular diseases, such as vascular stenosis, atherosclerosis, and abdominal aortic aneurysms.
AB - Cyclophilin A (CyPA) has been studied as a multifunctional protein that is upregulated in a variety of inflammatory conditions, such as rheumatoid arthritis, autoimmune disease, and cancer. CyPA has been classified as an immunophilin and has a variety of intracellular functions, including intracellular signaling, protein trafficking, and the regulation of other proteins activity. Besides its intracellular functions, CyPA is a secreted molecule that has a physiological and pathological role in cardiovascular diseases, making it a potential biomarker and mediator in cardiovascular diseases, such as vascular stenosis, atherosclerosis, and abdominal aortic aneurysms.
KW - Immunophilin
KW - Matrix metalloproteinase
KW - Reactive oxygen species
KW - Remodeling
KW - Vasculature
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U2 - 10.1253/circj.CJ-10-0904
DO - 10.1253/circj.CJ-10-0904
M3 - Review article
C2 - 20962430
AN - SCOPUS:78449257436
VL - 74
SP - 2249
EP - 2256
JO - Circulation Journal
JF - Circulation Journal
SN - 1346-9843
IS - 11
ER -