Abstract
Cyclophilin A (CyPA) has been studied as a multifunctional protein that is upregulated in a variety of inflammatory conditions, such as rheumatoid arthritis, autoimmune disease, and cancer. CyPA has been classified as an immunophilin and has a variety of intracellular functions, including intracellular signaling, protein trafficking, and the regulation of other proteins activity. Besides its intracellular functions, CyPA is a secreted molecule that has a physiological and pathological role in cardiovascular diseases, making it a potential biomarker and mediator in cardiovascular diseases, such as vascular stenosis, atherosclerosis, and abdominal aortic aneurysms.
| Original language | English |
|---|---|
| Pages (from-to) | 2249-2256 |
| Number of pages | 8 |
| Journal | Circulation Journal |
| Volume | 74 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2010 Nov 1 |
Keywords
- Immunophilin
- Matrix metalloproteinase
- Reactive oxygen species
- Remodeling
- Vasculature
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
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Cite this
Satoh, K., Shimokawa, H., & Berk, B. C. (2010). Cyclophilin A: Promising new target in cardiovascular therapy. Circulation Journal, 74(11), 2249-2256. https://doi.org/10.1253/circj.CJ-10-0904