Cycloamylose-based biomaterial: Nanogel of Cholesterol-bearing cationic cycloamylose for siRNA delivery

Sayaka Toita, Yuki Soma, Nobuyuki Morimoto, Kazunari Akiyoshi

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

A new siRNA delivery system made of a functional cycloamylose nanogel is reported. Cholesterol-bearing cationic cycloamylose formed nanogels by self-assembly in water. The nanogels formed 20-40 nm nanoparticles that bound to 21 bp siRNA. The complexes exerted an RNAi effect on SCC7-GL3 cells that stably express the luciferase gene.

Original languageEnglish
Pages (from-to)1114-1115
Number of pages2
JournalChemistry Letters
Volume38
Issue number11
DOIs
Publication statusPublished - 2009 Dec 1

ASJC Scopus subject areas

  • Chemistry(all)

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