Cyclin' toward dementia: Cell cycle abnormalities and abortive oncogenesis in Alzheimer disease

Arun K. Raina, Xiongwei Zhu, Catherine A. Rottkamp, Mervyn Monteiro, Atsushi Takeda, Mark A. Smith

Research output: Contribution to journalShort surveypeer-review

145 Citations (Scopus)

Abstract

Recent evidence has associated the aberrant, proximal re-expression of various cell cycle control elements with neuronal vulnerability in Alzheimer disease, a chronic neurodegeneration. Such ectopic localization of various cyclins, cyclin-dependent kinases, and cyclin inhibitors in neurons can be seen as an attempt to re-enter the cell cycle. Given that primary neurons are terminally differentiated, any attempted re-entry into the cell division cycle in this postmitotic environment will be dysregulated. Since successful dysregulation of the cell cycle is also the hallmark of a neoplasm, early cell-cycle pathophysiology in Alzheimer disease may recruit oncogenic signal transduction mechanisms and, hence, can be viewed as an abortive neoplastic transformation. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)128-133
Number of pages6
JournalJournal of Neuroscience Research
Volume61
Issue number2
DOIs
Publication statusPublished - 2000 Jul 15
Externally publishedYes

Keywords

  • Alzheimer disease
  • Cell cycle
  • Neoplasia
  • Neurodegeneration
  • Oncogenesis

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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