Abstract
This study describes the novel utility of cyclic sulfamidite as a simultaneous protecting group for 1,2- or 1,3-amino alcohols. An exceptionally mild and neutral condition for the removal of the cyclic sulfamidite was developed. The deprotection condition demonstrated a broad range of functional-group compatibility, including a substrate bearing a Z-enyne structure without any loss of double-bond stereochemistry.
Original language | English |
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Pages (from-to) | 996-1000 |
Number of pages | 5 |
Journal | Chemical and Pharmaceutical Bulletin |
Volume | 68 |
Issue number | 10 |
DOIs | |
Publication status | Published - 2020 |
Keywords
- Amino alcohol
- Cyclic sulfamidite
- Deprotection
- Protecting group
- Protection
ASJC Scopus subject areas
- Chemistry(all)
- Drug Discovery