Cyclic AMP-dependent memory mutants are defective in the food choice behavior of Drosophila

Katsunori Motosaka, Masayuki Koganezawa, Satoko Narikawa, Akira Furuyama, Kenji Shinozaki, Kunio Isono, Ichiro Shimada

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Acute choice behavior in ingesting two different concentrations of sucrose in Drosophila is presumed to include learning and memory. Effects on this behavior were examined for four mutations that block associative learning (dunce, rutabaga, amnesiac, and radish). Three of these mutations cause cyclic AMP signaling defects and significantly reduced taste discrimination. The exception was radish, which affects neither. Electrophysiological recordings confirmed that the sensitivity of taste receptors is almost indistinguishable in all flies, whether wild type or mutant. These results suggest that food choice behavior in Drosophila involves central nervous learning and memory operating via cyclic AMP signaling pathways.

Original languageEnglish
Pages (from-to)279-283
Number of pages5
JournalJournal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology
Volume193
Issue number2
DOIs
Publication statusPublished - 2007 Feb 1

Keywords

  • Feeding behavior
  • Ingestion
  • Learning and memory
  • Memory mutants
  • Taste

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Physiology
  • Animal Science and Zoology
  • Behavioral Neuroscience

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