Cyanamide synthesis by the palladium-catalyzed cleavage of a Si-N bond

Shin Kamijo, Tienan Jin, Yoshinori Yamamoto

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)


A palladium mimic of the Curtius rearrangement and a palladium-catalyzed geminal addition of a Si-N bond occurs in the high-yielding synthesis of cyanamides from isocyanides and trimethylsilyl azide in the presence of a palladium catalyst (see scheme). A wide range of functional groups are tolerated in the reaction.

Original languageEnglish
Pages (from-to)1780-1782
Number of pages3
JournalAngewandte Chemie - International Edition
Issue number10
Publication statusPublished - 2002 Jan 1


  • Amides
  • Azomethine ylides
  • Cycloaddition
  • Natural products
  • Synthetic methods

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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