CuX2-mediated [4+2] benzannulation as a new synthetic tool for stereoselective construction of haloaromatic compounds

Yukie Isogai, Menggenbateer, F. Nawaz Khan, Naoki Asao

    Research output: Contribution to journalArticlepeer-review

    44 Citations (Scopus)

    Abstract

    The CuX2-mediated reaction of enynal units, including ortho-alkynylbenzaldehydes, with alkynes gives a variety of haloaromatic compounds stereoselectively in good to high yields. 2,2′-Binaphthyl skeletons are also readily prepared by the reaction of ortho-alkynylbenzaldehydes and diynes. The method was applied to the synthesis of poly-substituted tetracene derivatives.

    Original languageEnglish
    Pages (from-to)9575-9582
    Number of pages8
    JournalTetrahedron
    Volume65
    Issue number46
    DOIs
    Publication statusPublished - 2009 Nov 14

    ASJC Scopus subject areas

    • Biochemistry
    • Drug Discovery
    • Organic Chemistry

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