CuX2-mediated [4+2] benzannulation as a new synthetic tool for stereoselective construction of haloaromatic compounds

Yukie Isogai; Menggenbateer; F. Nawaz Khan; Naoki Asao

doi:10.1016/j.tet.2009.09.061

CuX₂-mediated [4+2] benzannulation as a new synthetic tool for stereoselective construction of haloaromatic compounds

Yukie Isogai, Menggenbateer, F. Nawaz Khan, Naoki Asao

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

The CuX₂-mediated reaction of enynal units, including ortho-alkynylbenzaldehydes, with alkynes gives a variety of haloaromatic compounds stereoselectively in good to high yields. 2,2′-Binaphthyl skeletons are also readily prepared by the reaction of ortho-alkynylbenzaldehydes and diynes. The method was applied to the synthesis of poly-substituted tetracene derivatives.

Original language	English
Pages (from-to)	9575-9582
Number of pages	8
Journal	Tetrahedron
Volume	65
Issue number	46
DOIs	https://doi.org/10.1016/j.tet.2009.09.061
Publication status	Published - 2009 Nov 14

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tet.2009.09.061

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AU - Asao, Naoki

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CuX₂-mediated [4+2] benzannulation as a new synthetic tool for stereoselective construction of haloaromatic compounds

Abstract

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