Cutting edge: OX40 inhibits TGF-β- and antigen-driven conversion of naive CD4 T cells into CD25+Foxp3+ T cells

Takanori So, Michael Croft

Research output: Contribution to journalArticle

146 Citations (Scopus)

Abstract

Naive CD4 T cells can develop into regulatory T cells by acquiring the transcription factor Foxp3. Combined signals from the TCR, CD28, IL-2R, and TGF-βR promote Foxp3 expression in activated naive CD25- CD4 T cells. Here we show that OX40 (CD134) signaling inhibits TGF-β-driven Foxp3 mRNA and suppresses the conversion of naive Ag-specific transgenic CD4 T cells into CD25+Foxp3+ T cells. These data identify OX40 as a negative regulator of Foxp3 and suggest that OX40 can concomitantly promote effector T cell generation while antagonizing the differentiation of adaptive Foxp3+ regulatory T cells.

Original languageEnglish
Pages (from-to)1427-1430
Number of pages4
JournalJournal of Immunology
Volume179
Issue number3
DOIs
Publication statusPublished - 2007 Aug 1

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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