TY - JOUR
T1 - Cutting edge
T2 - OX40 inhibits TGF-β- and antigen-driven conversion of naive CD4 T cells into CD25+Foxp3+ T cells
AU - So, Takanori
AU - Croft, Michael
PY - 2007/8/1
Y1 - 2007/8/1
N2 - Naive CD4 T cells can develop into regulatory T cells by acquiring the transcription factor Foxp3. Combined signals from the TCR, CD28, IL-2R, and TGF-βR promote Foxp3 expression in activated naive CD25- CD4 T cells. Here we show that OX40 (CD134) signaling inhibits TGF-β-driven Foxp3 mRNA and suppresses the conversion of naive Ag-specific transgenic CD4 T cells into CD25+Foxp3+ T cells. These data identify OX40 as a negative regulator of Foxp3 and suggest that OX40 can concomitantly promote effector T cell generation while antagonizing the differentiation of adaptive Foxp3+ regulatory T cells.
AB - Naive CD4 T cells can develop into regulatory T cells by acquiring the transcription factor Foxp3. Combined signals from the TCR, CD28, IL-2R, and TGF-βR promote Foxp3 expression in activated naive CD25- CD4 T cells. Here we show that OX40 (CD134) signaling inhibits TGF-β-driven Foxp3 mRNA and suppresses the conversion of naive Ag-specific transgenic CD4 T cells into CD25+Foxp3+ T cells. These data identify OX40 as a negative regulator of Foxp3 and suggest that OX40 can concomitantly promote effector T cell generation while antagonizing the differentiation of adaptive Foxp3+ regulatory T cells.
UR - http://www.scopus.com/inward/record.url?scp=34548646019&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34548646019&partnerID=8YFLogxK
U2 - 10.4049/jimmunol.179.3.1427
DO - 10.4049/jimmunol.179.3.1427
M3 - Article
C2 - 17641007
AN - SCOPUS:34548646019
VL - 179
SP - 1427
EP - 1430
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 3
ER -