Cutting edge: Histamine receptor H4 activation positively regulates in vivo IL-4 and IFN-γ production by invariant NKT cells

Maria C. Leite-de-Moraes, Séverine Diem, Marie Laure Michel, Hiroshi Ohtsu, Robin L. Thurmond, Elke Schneider, Michel Dy

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)

Abstract

Histamine (HA) is a biogenic amine with multiple activities in the immune system. In this study we demonstrate that histamine-free histidine decarboxylasedeficient (HDC-/-) mice present a numerical and functional deficit in invariant NK T (iNKT) cells as evidenced by a drastic decrease of IL-4 and IFN-γ production. This deficiency was established both by measuring cytokine levels in the serum and intracellularly among gated iNKT cells. It resulted from the lack of HA, because a single injection of this amine into HDC-/- mice sufficed to restore normal IL-4 and IFN-γ production. HA-induced functional recovery was mediated mainly through the H4 histamine receptor (H4R), as assessed by its abrogation after a single injection of a selective H4R antagonist and the demonstration of a similar iNKT cell deficit in H4R-/- mice. Our findings identify a novel function of HA through its H4R and suggest that it might become instrumental in modulating iNKT cell functions.

Original languageEnglish
Pages (from-to)1233-1236
Number of pages4
JournalJournal of Immunology
Volume182
Issue number3
DOIs
Publication statusPublished - 2009 Feb 1

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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